咳喘宁胶囊对慢性支气管炎大鼠血清、肺组织及支气管肺泡灌洗液GSH和GSH-Px活性的影响  

The Effect of Kechuanning Capsules on GSH and GSH-Px Activity in the Blood Serum, Lung Tissue and Bronchial Alveoli Lavage Fluid (BALF) of Rat with Chronic Bronchitis

作　　者：杨牧祥[1] 方朝义[1] 杨宝元[2] 艾发元 曹刚[1] 李华[1] 

机构地区：[1]河北医科大学中医学院,石家庄050091 [2]唐山卫校附属医院

出　　处：《中国中医药信息杂志》2001年第12期41-43,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：河北省科技厅资助项目(№:97276157B)

摘　　要：目的:探讨咳喘宁胶囊对实验性慢性支气管炎的治疗作用机制。方法:采用改良烟熏法复制大鼠慢性支气管炎模型,实验分组为模型组、咳高组、咳低组、桂龙组,并设不加处理的正常对照组。以高、低剂量咳喘宁和桂龙咳喘宁进行干预,测定各组大鼠血清、肺组织及支气管肺泡灌洗液(BALF)中谷胱甘肽(GSH)和谷胱甘肽过氧化物酶(GSH-Px)的含量。结果:模型组大鼠血清、肺组织及BALF中GSH和GSH-Px含量均较正常组明显降低(P<0.01)。与模型组比较,治疗各组血清、肺组织及BALF中GSH和GSH-Px含量均明显增高(P<0.05或P<0.01);咳高组血清、肺组织及BALF中GSH和GSH-Px含量均高于桂龙组与咳低组(P<0.05或P<0.01)。结论:咳喘宁胶囊可显著提高大鼠GSH和GSH-Px活性,增强机体抗氧化损伤能力。Objective : Research on the internal mechanism of treating experimental chronic bronchitis with Kechuanning capsules. Method : We duplicated the animal model of chronic bronchitis with refined smoking-fumigated method, divided the groups into model group, high dose group, low dose group, Guilong group as well as control group, made intervention with high and low dose of Kechuanning as well as Guilong Kechuanning (another medicine of the similar kind) and determined GSH and GSH-Px contents in the blood serum, lung tissue and BALF of each group. Results : The GSH and GSH-Px contents in the blood serum, lung tissue and BALF of the model group were significantly reduced than the normal group(P<0.01). The GSH and GSH-Px contents in the blood serum,lung tissue and BALF in each treatment group were all higher than that of the model group(P<0.05 or P<0.01);The GSH and GSH-Px contents in the blood serum, lung tissue and BALF in the high dose group were higher than that of the Guilong group and low dose group(P<0.05 or P<0.01). Conclusion : Kechuanning capsules could increase the GSH and GSH-Px activity of the rat markedly and improve the antioxidation injury ability of the organism.

关 键 词：咳喘宁胶囊 慢性支气管炎 GSH GSH-Px中医药疗法 动物实验 

分 类 号：R259.622.1[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]