系统性红斑狼疮患者医院获得性支气管-肺感染的临床分析  

Study of nosocomial bronchopulmonary infection in patients with systemic lupus erythematosus

作　　者：褚爱春[1] 陈国忠[1] 杨淑红[1] 

机构地区：[1]湖北省武汉大学人民医院内科,430060

出　　处：《中国全科医学》2002年第1期26-27,共2页Chinese General Practice

摘　　要：目的　研究系统性红斑狼疮 (SLE)患者医院获得性支气管 -肺感染 (NBPI)的状况。方法　回顾性分析我院 1996年 1月～ 2 0 0 0年 4月间住院的SLE患者并发NBPI的临床资料。结果　SLE并发NBPI的发生率为41 9%。NBPI发病前半月内均使用过抗生素 ,其中 3种以上抗生素联用的达 5 6 6 % ,使用激素与环磷酰胺 (CTX)等免疫抑制剂者并发NBPI的发生率分别达 5 2 6 %和 80 4%。中、重度狼疮活动评分组NBPI发生率与轻度活动评分组相比差异有显著性意义 (P <0 0 0 5 )。合并NBPI者在住院时间、住院费用、死亡率方面与未并发NBPI者相比 ,差异具有显著性意义 (P <0 0 5 )。结论　抗生素滥用和狼疮活动评分与NBPI有密切关系 ,积极有效控制SLE患者的病情及合理用药是预防NBPI的主要措施。Objective To investigate the state of nosocomial bronchopulmonary infection(NBPI) in patients with systemic lupus erythematosus(SLE).Methods We analyzed the clinical data of SLE with NBPI in our hospital from Jan.1996 to Apr.2000.Results The dada showed that the percentage of SLE with NBPI was 41 9%(83/198).All the patients with NBPI investigated were administered antibiotics during hospitalized stay.In using steroid and immunosuppression,the percentage of NBPI were 52 6% and 80 4% respectively.The percentage of NBPI was correlated with the activity measurement of the cases with SLE(P<0 005).There was evidently difference about the length of stay,economic burden and mortality between SLE and SLE with NBPI(P<0 05).Conclusion NBPI is associated with the measure of SLE activity and antibiotic drugs widely.Positive and effective control of SLE is primary measure of the prevention of NBPI.

关 键 词：支气管-肺部感染 医院感染 系统性红斑狼疮 临床分析 NBPI 

分 类 号：R593.241[医药卫生—内科学] R56[医药卫生—临床医学]