雷公藤榕碱的结构与分离  

ISOLATION AND STRUCTURE OF WILFORDLONGING FROM TRIPTERYGIUM WILFORDII HOOK .F.

作　　者：林绥[1] 李援朝[2] 樱井信子 曹剑虹[1] 邓思珊[1] 夏志林[1] 谢狄霖[1] 

机构地区：[1]福建省医学科学研究所,福建福州350001 [2]中国科学院上海药物研究所,上海200031 [3]日本星药科大学

出　　处：《药学学报》2002年第2期128-130,共3页Acta Pharmaceutica Sinica

基　　金：福建省科委重点项目 (99 7 16)

摘　　要：目的　研究雷公藤 (TripterygiumwilfordiiHook .f.)的化学成分。方法　应用各种色谱技术进行分离纯化 ,用UV ,IR ,MS ,HRMS ,1 HNMR ,1 3CNMR(COM和OFR) ,1 H 1 HCOSY ,1 H 1 3CCOSY ,2D NOESY ,1 H 1 3CCOLOC鉴定化合物的结构。结果　分离并鉴定了 2个生物碱 :I为wilforgine ,II为雷公藤榕碱 (wilfordlongine)。AIM To study the chemical composition of Tripterygirm wilfordii Hook.f. METHODS Colunm chromatography was used to separate the chemical constituents. UV, IR, MS, HRMS, 1HNMR , 13 CNMR (COM and OFR), 1H 1H COSY, 1H 13 C COSY, NOESY and COLOC spectra were used to determine the structures of the isolated constituents. RESULTS Two sesquiterpene alkaloids were isolated and their structures were elucidated as wilforgine and wilfordlongine on the basis of spectral evidence. CONCLUSION Wilfordclonine is a new sesquiterpene alkaloid.

关 键 词：雷公藤 倍半萜生物碱 wilforgine 雷公藤榕碱 植物药 中药 

分 类 号：R282.71[医药卫生—中药学] R284[医药卫生—中医学]