亲体部分肝移植治疗肝豆状核变性  

Living related partial liver transplantation in the treatment of Wilson's disease

作　　者：王学浩[1] 张峰[1] 李相成 钱建民 陆森 孔连宝 张浩 孙倍成 王科 胡建平 陈吉庆 

机构地区：[1]医科大学第一附属医院肝脏移植中心,南京210029

出　　处：《中华器官移植杂志》2002年第2期75-77,共3页Chinese Journal of Organ Transplantation

基　　金：江苏省政府重点资助课题 (BJ980 2 5);江苏省青年基金资助项目(BJ980 2 );江苏省卫生厅重点资助项目(H9517)

摘　　要：目的　研究亲体部分肝移植术在肝豆状核变性 (Wilson’s病 )治疗中的应用价值。方法　 2 0 0 1年 1月至 2 0 0 1年 1 2月连续为 1 0例Wilson’s病患者施行肝移植术 ,供肝者均为患者的母亲。结果　手术全部获得成功 ,术后无严重并发症发生 ,均恢复顺利。术后铜氧化酶均显著升高 ,分别从术前 (9.9± 9.3)U/L升高至术后 (1 2 4 .0± 33 .8)U/L ;角膜缘K F环均明显变淡 ;神经系统症状改善 ;现已分别存活 1 2、1 1、1 0、8、7、7、3、3、2和 1个月。结论　肝移植术是治疗肝豆状核变性的有效手段。亲体部分肝移植术具有供肝来源可靠、临床疗效好、费用低的优点 ,应用前景广阔。Objective To explore the significance of living related liver transplantation in the treatment of Wilson's disease (hepatolenticular degeneration).Methods Living related partial liver transplantation was performed on 10 patients with Wilson's disease from Jan. 2001 to Dec. 2001. All the donors were the mothers of 10 patients.Results All the operations were successful. No case died during the operation. No severe complication occurred after surgery. Ceruloplasmin was increased from ( 9.9 ± 9.3 )?U/L to ( 124.0 ± 33.8 )?U/L. Ten cases had survived for 12 months, 11 months, 10 months, 8 months, 7 months, 7 months, 3 months, 3 months, 2 months and 1 month, respectively.Conclusion Liver transplantation is an effective method in the treatment of Wilson's disease.

关 键 词：肝豆状核变性 肝移植 活体供者 亲体部分肝移植 治疗 

分 类 号：R657.3[医药卫生—外科学]