持续植物状态^(99)Tc^m-ECD脑SPECT显像  

Significance of rCBF level determined by ^(99)Tc^m-ECD SPECT to the evaluation of the therapeutic effects and of the prognosis predicting for persistent vegetative state patients

作　　者：孟娟[1] 潘晓雯[1] 朱家瑞[2] 川玲[2] 

机构地区：[1]海军总医院全军高压氧中心,北京100037 [2]海军总医院核医学科,北京100037

出　　处：《中华核医学杂志》2002年第1期12-13,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的　观察持续植物状态 (PVS)患者脑血流灌注情况及其对高压氧配合药物治疗疗效和预后判断的意义。方法　用99Tcm 双半胱乙酯 (ECD)局部脑血流 (rCBF)显像方法对 2 6例不同病因所致的PVS患者进行了检查 ,9例进行了动态观察。结果　 2 6例PVS患者脑血流灌注均显示异常 ,其部位可与脑CT或MRI检查相符或不符 ,随病情恢复 ,脑血流灌注亦恢复正常。结论　99Tcm ECD脑SPECT显像观察rCBF可反映PVS患者脑血流灌注情况 ,并可作为高压氧配合药物治疗PVS疗效及预后判断的指标。Objective To observe the infusion state of cerebral blood flow in persistent vegetative state (PVS) patients and its significance to the effects of hyperbaric oxygen (HBO) and medical treatment and to the prognosis predicting. Methods Twenty-six patients with PVS received regional cerebral blood flow (rCBF) examination with 99 Tc m-ethylcysteinate dimer (ECD) SPECT, 9 of the 26 cases underwent a dynamic study. Results All of the 26 cases were with abnormal cerebral blood flow level. Some abnormal rCBF areas were concordant with the changes on brain CT or MRI, but some were not.As PVS recovered,improvement of rCBF or complete return to normal were also observed. Conclusions rCBF determined with 99 Tc m-ECD SPECT is a safe and reliable modality,which not only can directly reflect the level of cerebral blood flow and serve as a supplementary work-up to brain CT and MRI, but also can be used to monitor the effect of HBO and medical treatment for PVS and to predict the prognosis.

关 键 词：持续植物状态 脑血流灌注 ^99TC^M-ECD SPECT 预后 判断 

分 类 号：R817[医药卫生—影像医学与核医学]