血清C反应蛋白在冠状动脉成形术后的变化  

Changes of the serum level of C-reactive protein after coronary angioplasty

作　　者：杜同信[1] 王自正[1] 王书奎[1] 孙君江[1] 傅雷[1] 刘志忠[2] 段宝祥[2] 

机构地区：[1]南京医科大学附属南京第一医院放免中心,210006 [2]南京医科大学心血管研究所,210006

出　　处：《中华核医学杂志》2002年第1期46-47,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的　观察经皮冠状动脉腔内成形术 (PTCA)后血清C反应蛋白 (CRP)的变化。方法选择不稳定型心绞痛 (UA)患者 47例 ,用免疫放射分析法 (IRMA)分别测定PTCA术前、术后 48h及术后 1周血清CRP值 ,并随访 9个月内临床再狭窄发生率 ,比较再狭窄组与无再狭窄组间血清CRP值 ,另 2 5例检测冠脉造影 (CAG)术前、术后 48h的血清CRP值作为对照。结果　PTCA术后 48hCRP较术前明显升高 (P <0 .0 1) ,而术后 1周CRP值和术前无差异 ,CAG术前、术后的CRP无明显变化。随访期间有 13例患者诊断为临床再狭窄 ,其术后 48hCRP较非再狭窄组明显增高 (P <0 .0 1)。结论　PTCA术后 48h血清CRP较术前增高 ,与PTCA术后远期临床疗效有关。Objective To study the changes of C-reactive protein level (CRP) after percutaneous transluminal coronary angioplasty (PTCA) and its relation with clinical outcome after the operation. Methods Serum levels of CRP in 47 patients with unstable angina pectoris were measured via immunoradiometric assay (IRMA), before and 48 h, 1 week after operation. Incidence of restenosis was observed within a 9 months follow-up and the CRP levels of the patients with restenosis were compared with those of the patients without restenosis, CRP levels before and 48 h after coronary angiography in 25 cases were used as the controls. Results The mean CRP level at 48 h after PTCA operation was significantly higher than that before operation ( P <0.01), while no differences between those at l week before and after PTCA operation and no significant difference between those of before and after coronary angiography operation were observed. Clinical restenosis was confirmed in 13 patients in the follow-up period and their CRP levels at 48 h after operation were significantly higher than that in the patients without restenosis( P <0.01). Conclusion Serum CRP levels at 48 h after PTCA operation were significantly higher than that before operation and it correlated closely with the clinical outcome.

关 键 词：冠心病 冠状动脉成形术 血清C反应蛋白 PTCA 免疫放射分析 

分 类 号：R541.4[医药卫生—心血管疾病] R654.2[医药卫生—内科学]