青心酮三种给药途径的生物利用度比较研究  

Comparison of Bioavailability of Qingxintong by Three Administration Routes

作　　者：庞雪冰[1] 付官铭[1] 左明达[1] 

机构地区：[1]华中科技大学同济医学院计划生育研究所,武汉430030

出　　处：《中药新药与临床药理》2002年第1期31-32,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：以 3种给药途径在恒河猴体内进行青心酮生物利用度比较。实验结果表明 :青心酮在动物体内具有吸收快 ,消除快的特点 ,肌肉注射与灌胃给药的吸收半衰期在 0 .0 5～ 0 .0 7h之间 ,消除半衰期在 0 .14～ 0 .2 9h之间。肌肉给药 10mg/kg的剂量与静脉给药相同剂量的相对生物利用度为 94 .71%。灌胃给药 6 0mg/kg剂量与静脉给药 10mg/kg的剂量相对生物利用度仅为 9.16 %。The in-vivo bioavailability of Qingxintong administrated by intramuscular injection, intravenous injection and gastric infusion was compared. Experimental results showed that Qingxintong was rapidly absorbed and excreted. The half-life time for absorption was 0.05 - 0.07 h and the half-life time for elimination was 0.14 - 0.29 h. The bioavailability of Qingxintong in the dose of 10 mg/kg by intramuscular injection or by intravenous injection was 94.71 %, and was 9.16% in the dose of 60 mg/kg by gastric infusion or in the dose of 10mg/kg by intramuscular injection.

关 键 词：青心酮 药代动力学 高压液相色谱法 比较研究 

分 类 号：R285.5[医药卫生—中药学]