九分喷雾剂透皮吸收接收液的筛选  

Screening of the Receiving Solution in Transdermal Absorption of Jiufen Spray

作　　者：孙亦群[1] 周莉玲[1] 陈孝银[2] 

机构地区：[1]广州中医药大学,广州510405 [2]暨南大学医学院,广州510632

出　　处：《中药新药与临床药理》2002年第1期45-46,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的筛选九分喷雾剂中士的宁透皮吸收研究所用的接收液。方法以改良Franz扩散池为实验装置 ,大鼠腹部皮肤为渗透皮肤 ,以回收率、Q -T方程和透皮速率常数为考察指标 ,从生理盐水、生理盐水 -乙醇 (7∶3,v∶v)、pH 6 .8磷酸盐缓冲液 -乙醇 (8∶2 ,v∶v)、含 2 5 %乙醇的pH 7.4磷酸盐缓冲液中筛选最佳接收液。结果综合比较日内回收率、日间回收率、Q -T方程和透皮速率常数 ,均以生理盐水 -乙醇 (7∶3,v∶v)为最佳。结论生理盐水 -乙醇 (7∶3,v∶v)是适合作为九分喷雾剂中士的宁透皮吸收研究的接收液。Objective: To screen the receiving solution used to study the transdermal absorption of strychnine in Jiufen spray. Methods: With recovery,Q-T equation and transdermal speed constant as the parameters, the improved Franz-cell and the skin of SD rats were used to screen the receiving solution from saline, saline-alcohol (7∶3,v∶v), pH phosphate buffer solution-alcohol (88∶2,v∶v), pH 7.4 phosphate buffer containing 25% alcohol. Results: The comparison of the inter-day and intra-day recoveries,Q-T equation and transdermal speed constant showed that saline-alcohol(7∶3) was the best for the study. Conclusion: It is indicated that saline-alcohol(7∶3) was the best receiving solution for the transdermal absorption study of Jiufen spray.

关 键 词：九分喷雾剂 生产 制备 士的宁 透皮吸收 接收液 中药 

分 类 号：R284.1[医药卫生—中药学]