科尔兴胶囊的毒理学研究  

Toxicologic Study on Ke'erxing Capsules

作　　者：胡丽萍[1] 赵秀萍[1] 张惠颖[1] 马杰[1] 

机构地区：[1]辽宁省中医研究院,沈阳110034

出　　处：《中药新药与临床药理》2002年第1期20-22,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的观察动物ig科尔兴胶囊的急性毒性和长期毒性。方法以最大浓度、最大体积的科尔兴胶囊ig小鼠 1次 ,测定最大耐受量。以高、中、低 3个剂量的科尔兴胶囊ig大鼠连续 8周 ,观察大鼠的生长发育、血液学、血液生化学、脏器系数、组织病理学变化及停药 2周后上述指标的变化。结果小鼠 1d内 1次ig科尔兴胶囊的最大耐受量≥ 4 0 0 0mg/kg。高剂量科尔兴胶囊组大鼠出现行动迟缓 ,反应迟钝等一般行为变化及体重增长缓慢的趋势 ;高、中剂量组大鼠出现前列腺脏器系数增高 ,但停药 2周后均恢复正常。其它各指标均无明显变化。结论ig科尔兴胶囊对小鼠、大鼠均有一定影响 ,但此影响是可逆的。Objective: To observe the acute toxicity of Ke'erxing Capsules (KC) in mice and its long-period toxicity in rats. Methods: The maximal tolerance dose was tested by gastric infusion of single oral dose of KC. Three groups of rats (in high, moderate and low dosage of KC) were administered with repeated gastric infusion of KC for 8 weeks. Body weight, hematological and hematobiochemical parameters, coefficient and histomorphological figure of organs (the heart, liver, spleen, lungs, kidneys, adrenals, testes, prostate, pancreas, uterus, brain, thymus) were examined in 8 weeks and 2 weeks after the cessation of KC. Results: The oral maximal tolerance dose of KC in mice was more than 4000 mg/kg (equal to 600 times of clinical dose). General conditions were changed and the body weight was increased slowly in high-dosage group. The coefficient of prostate was increased in high-dosage group and moderate-dosage group and recovered to normal 2 weeks after stopping the drug. Conclusion: KC has a certain effect on mice and rats but the effect was reversible.

关 键 词：科尔兴胶囊 药理学 毒性 中毒 

分 类 号：R285.1[医药卫生—中药学]