螺旋藻对模拟失重大鼠钙代谢和骨矿盐密度影响的初步研究  

Effects of spirulina on changes of femur BMD and calcium metabolism in rats simulatied weightlessness

作　　者：黄纪明[1] 白树民[1] 胡志祥 杨春雷 朱德兵[1] 李志霞[1] 洪建武[1] 

机构地区：[1]航天医学工程研究所,北京100094 [2]云南施普瑞有限责任公司

出　　处：《中国骨质疏松杂志》2002年第1期51-54,共4页Chinese Journal of Osteoporosis

摘　　要：目的　研究螺旋藻对模拟失重大鼠钙代谢和骨矿盐密度的影响。方法　 30只雄性SD大鼠随机分为 3组 (每组 10只 ) :A组 :地面自由活动组 (饲喂普通饲料 ) ;B组 :模拟失重普通饲料组 ;C组 :模拟失重螺旋藻组 ,实验期 2 1d。结果　B组大鼠饲料钙的表观吸收率、后肢骨密度(BMD)、骨钙含量以及骨钙素 (BGP)的水平显著性低于A组 ,血钙水平明显高于A组 ;C组饲料钙的表观吸收率、骨密度、骨钙含量以及骨钙素水平较B组高 ,血钙水平显著性低于B组。结论　螺旋藻可以减少模拟失重大鼠后肢骨质的丢失 ,提高骨骼BMD ,增加骨形成 。Objective\ To stduy the the effects of spirulina on changes in femur BMD and calcium metabolism in rats simulated weightlessness. Methods\ 30 male SD rats were divided into three groups: one free control group (group A) and two groups with simulated wightlessness (group B and C). Group A and B were fed normal diet, group C fed with normal diet supplemented with 5% (w/w) spirulina,all rat's drank pure water ad libitum. Results\ (1) In group B, the apparent absorption rate of the dietary calcium, the calcium content of femur, the serum BGP and the femur BMD were significantly lower than those in group A, whereas the concentration of serum calcium was markedly higher than that in group A. (2)In group C, the apparent absorption rate of the dietary calcium, the calcium content of femur, the femur BMD, and the serum BGP were significantly higher than those in group B, but the concentration of serum calcium was remarkably lower than that in group B. Conclusion\ Spirulina can stimulate the activity and formation of osteocytes, definitely decrease bone loss, and enhance BMD in rats simulated weightlessness.

关 键 词：螺旋藻 模拟失重 骨矿盐密度 血钙 骨钙素 骨钙 表观吸收率 大鼠 

分 类 号：R282.710.5[医药卫生—中药学]