妊娠合并系统性红斑狼疮患者应用DNA免疫吸附治疗后的妊娠结局  

Outcome of pregnancy with systemic lupus erythematosus treated with DNA immunoabsorbent

作　　者：李桂芬 赵允[2] 李艳玲[2] 王爱婷[3] 李治玖 蔺恩富 陈长治[5] 俞耀庭[5] 

机构地区：[1]山东省淄博市第一医院妇产科,255200 [2]山东省淄博市妇幼保健院 [3]山东省潍坊市妇幼保健院 [4]山东省淄博市中心医院 [5]南开大学分子生物学研究所

出　　处：《中华妇产科杂志》2002年第3期139-141,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨DNA免疫吸附治疗用于妊娠合并系统性红斑狼疮 (SLE)患者的临床效果。方法　对 6 9例妊娠合并SLE患者随机进行免疫吸附治疗 35例 (治疗组 )和常规治疗 34例 (对照组 )。将治疗组的动脉血流经DNA免疫吸附剂 (罐 ) ,然后由静脉回输至体内。比较两组的妊娠结局和并发症发生情况。结果　妊娠并发症 [妊娠高血压综合征 (妊高征 )、胎盘功能不全、流产等 ]发生率 :治疗组为 2 8 6 %、对照组为 85 3% ,两组比较 ,差异有极显著性 (P <0 0 1) ;胎儿丢失率 :治疗组为 2 0 0 %、对照组为 5 8 8% ,两组比较 ,差异有极显著性 (P <0 0 1)。早产儿发生率 :治疗组为 8 6 %、对照组为2 6 5 % ,两组比较 ,差异有显著性 (P <0 0 5 )。结论　DNA免疫吸附治疗妊娠合并SLE 。Objective To study the outcome of pregnancy with systemic lupus erythematosus (SLE) treated by DNA immunoabsorbent therapy Methods Sixty nine SLE women with pregnancy were randomly enrolled into DNA immunoabsorbent group (35, group Ⅰ) and common therapeutic group (34, group Ⅱ) as control Outcomes of pregnancy and complications were analyzed Results The incidence of complication and fetus loss in group Ⅰ was 28 6% (10 cases) and 20 0% (7 cases), while 85 3% (29 cases) and 58 8% (20 cases) in group Ⅱ, there was very significant difference respectively ( P <0 01) The incidence of premature birth was 8 6% (3 cases) in group Ⅰ, 26 5% (9 cases) in group Ⅱ, the difference was significant ( P <0 05). Conclusion DNA immunoabsorbent was more efficient than common therapy in the management of SLE with pregnancy

关 键 词：妊娠并发症 系统性红斑狼疮 妊娠结局 免疫吸附剂 DNA免疫吸附治疗 

分 类 号：R714.25[医药卫生—妇产科学] R593.241[医药卫生—临床医学]