不同碘摄入水平对人群甲状腺自身免疫反应的影响  

Influence on the thyroid autoimmunoreaction of people on different iodide intake

作　　者：刘迎迎[1] 项建梅[1] 阎玉芹[1] 陈祖培[1] 赵金扣 苏 华[3] 

机构地区：[1]天津医科大学内分泌研究所,天津300070 [2]江苏省卫生防疫站,江苏南京210009 [3]天津商学院,天津300040

出　　处：《中国地方病学杂志》2002年第2期84-87,共4页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金资助项目(39900125);教育部高等学校骨干教师资助计划资助项目(2000143)

摘　　要：目的 观察不同碘饮食水平对垂体甲状腺功能及外周血甲状腺抗体的影响。方法 选择江苏省徐州高碘病区17～18岁学生,分为高碘甲肿组（HIG）及高碘非甲肿组（HI）,选择天津18～19岁学生为适碘对照组（NI）。用放免法测定血清TT3、TT4、FT3、FT4、TGAb、TPOAb,IRMA法测定sTSH浓度,酶免法测定TSI及TRAb。结果 HIG及 HI组血清中sTSH明显高于 NI组;HIG及 HI组 FT3不同程度降低,尤其以 HI组为著;HIG及 HI组 TT3水平代偿性升高;组间 TT4及 FT4差异无显著意义。HIG与 HI组比较,所测定激素指标差异均无显著意义。血清甲状腺抗体结果显示,HIG组 TGAb及 TPOAb较 HI组明显升高,较NI组仅呈升高趋势,差异无显著意义;HIG及HI组TRAb明显高于NI组;HI组TGAb明显低于NI组;HI组的TSI及TPOAb与NI组差异无显著意义。结论 长期摄入过量碘诱发人群亚临床甲状腺功能低下,并使碘致性甲状腺肿患者甲状腺自身免疫反应增强。Objective To study the iodine effect on pituitary-thyroid function and immunoreaction in students on different iodide intake. Methods The target groups, aged 17～18 yrs, from high iodine area of Xuzhou including high iodine goiter(HIG) and no-goiter(HI) students were compared with the control group(NI), aged 18～19 yrs, from adequate iodine area of Tianjin. Serum TT4, TT3, FT4, FT3, TGAb and TPOAb were determined by RIA, TSH was measured by IRMA and TRAb and TSI were tested by ELISA. Results Compared with NI group, TSH in both group of HIG and HI increased remarkably while TT3 raised compensatively . FT3 slightly but marked reduced in HI and showed only low trend without statistic difference in HIG compared with NI group. All subjects' FT3 were tested within normal range. TT4 and FT4 indicated no difference among three groups. There was no statistic difference for all observed hormones between HIG and HI. TGAb and TPOAb in HIG group were greatly higher than that of HI but only slightly higher than that of NI. TRAb in HIG and HI increased while TGAb of NI declined significantly compared with NI. TSI and TPOAb showed no difference com pared with NI. Conclusions High iodine diet for a long period may induce subclinical hypothyroidism and enhanced the thyroid immunoreactions in human iodine induced goiter.

关 键 词：碘过多 碘摄入水平 甲状腺自身免疫反应 甲状腺抗体 甲状腺功能 亚临床甲状腺功能低下 

分 类 号：R581.9[医药卫生—内分泌]