高血压病患者与正常人血清胶原代谢的对比研究  

The comparison of serum collagen metabolism between essential hypertension and normal control

作　　者：梁茜[1] 李榕生[1] 林爱珍[2] 

机构地区：[1]广东省佛山市第一人民医院心内科,佛山市528000 [2]广东省佛山市第一人民医院检验科

出　　处：《岭南心血管病杂志》2002年第1期15-17,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的　测定高血压病 (EH)患者血清Ⅰ型前胶原羧基端肽 (PⅠP)、Ⅲ型前胶原氨基端肽 (PⅢP)和Ⅰ型胶原羧端交联肽 (ICTP)水平的改变 ,探讨其在高血压性心肌纤维化中的诊断价值。方法　采用放射免疫法测定 4 2例EH患者、30例正常对照者血清PⅠP、PⅢP及ICTP浓度 ,并对结果进行统计学分析。结果　EH患者血清PⅠP、PⅢP的含量分别为 (12 1 2± 2 0 8) μg/L和 (5 2± 3 2 ) μg/L ,明显高于正常对照组 (分别为 92 8μg/L± 13 3μg/L和 3 8μg/L±1 5 μg/L) ,P <0 0 5 ;ICTP的含量EH组虽有增加的趋势 (4 4± 1 7) μg/L ,但与正常组 (4 1± 1 5 )μg/L相比 ,P >0 0 5。有左心室肥厚 (LVH)的EH患者血清PⅠP水平高于无左心室肥厚 (无LVH)组 (12 7 6 μg/L± 18 5 μg/Lvs 10 5 3μg/L±12 4 μg/L,P <0 0 5 ) ,有LVH组血清ICTP水平低于无LVH组 (4 2 μg/L± 1 1μg/Lvs 5 0 μg/L± 1 2 μg/L ,P <0 0 5 ) ,而PⅢP水平两组无统计学差异 (P >0 0 5 )。结论　EH患者可能有Ⅰ型胶原及Ⅲ型胶原的合成增加 ,降解相对不足 ,测定PⅠP。Objective To investigate serum concentration of procollagen type Ⅰ carboxyterminal peptide (PⅠP), type Ⅲ aminoterminal peptide (PⅢP) and type Ⅰ collagen telopeptide (ICTP) in essential hypertension (EH). Methods Serum levels of PⅠP, PⅢP and ICTP in 42 EH patients and 30 healthy control were measured by radioimmunoassays. Results In EH patients, serum concentration of PⅠP, PⅢP was significantly higher than that in 30 healthy control. Although EH patients did tend to exhibit a higher serum ICTP concentration than normal control subjects, the difference was not statistically significant. EH patients with left ventricular hypertrophy exhibited higher values of PⅠP ( P <0 05) and lower values of ICTP ( P <0 05) than EH patients without left ventricular hypertrophy. No significant difference was noted between the serum PⅢP of the EH patients with and without left ventricular hypertrophy ( P >0 05 ). Conclusion The results suggest that PⅠP and PⅢP are sensitive serum markers of myocardial collagen synthesis. Myocardial fibrosis may be due to the excessive synthesis and insufficient degradation of collagen. PⅠP, PⅢP and ICTP may be indirect markers of myocardial fibrosis.

关 键 词：高血压病 心肌纤维化 胶原 EH PIP PⅢP ICTP 

分 类 号：R544.1[医药卫生—心血管疾病]