系统性红斑狼疮患者血清IL-18和sFas/sFasL的变化及相关性研究  

CORRELATION AND CHANGE OF SERUM IL-18 AND SOLUBLE SFAS/SOLUBLE FAS LIGAND IN SYSTEMIC LUPUS ERYTHEMATOSUS

作　　者：李富荣 戴勇 王沙燕 齐晖 黄瑞芳 李体远 

机构地区：[1]广东省深圳市人民医院,518020

出　　处：《中国现代医学杂志》2002年第6期13-15,共3页China Journal of Modern Medicine

摘　　要：目的 :研究系统性红斑狼疮 (SLE)血清IL - 18和可溶性sFas/可溶性sFas配体 (sFas/sFasL)的变化及相关性。方法 :采用ELISA检测 4 5例SLE患者和 18例正常人群血清中IL - 18,sFas及sFasL水平。结果 :SLE各组sFas/sFasL水平与正常对照组比较 ,差异具有非常显著性意义 (P <0 .0 1) ,其中相对活动期sFas较相对缓解期明显增高 (P <0 .0 1) ,sFasL无明显差异 (P >0 .0 5 )。IL - 18水平在SLE患者显著高于正常对照组 (P<0 .0 1) ,相对活动期患者较正常对照组和相对缓解期患者差异显著 (P <0 .0 1) ,而相对静止期患者血清水平则与正常对照组无明显差异 (P >0 .0 5 )。SLE患者和相对活动期患者血清IL - 18水平与sFas增高呈显著的正相关 (P <0 .0 1)。结论 :IL - 18,sFas及sFasL在SLE发病中有一定意义 ,IL -Objective:To investigate the correlation and change of serum IL-18 and sFas/sFasL in systemic lupus erythematosus (SLE).Methods:Level of IL-18 and sFas/sFasL from 45 patients with SLE and 18 normal control were determined with sandwich ELISA.Results:sFas/sFasL level of patient group with SLE were significantly higher compared with control group ( P <0.01).The level of sFas in active SLE patients were significantly higher than that of the inactive SLE patients ( P <0.01),but there was no significantly difference in sFasL level between active SLE patient and inactive SLE patients ( P >0.05).The level of IL-18 in SLE patient group was significantly higher than that of control group ( P <0.01).The level of IL-18 in active SLE patients were significantly higher than that of the inactive SLE patients ( P <0.01).Furthermore,there was no significant difference between inactive SLE patients and control group ( P >0.05).In addition ,there was significantly positive correlation between level of IL18 and sFas in SLE patient group and active SLE patient group( P <0.01).Conclusions:Level of IL-18 and sFas/sFasL significantly increase in the patients with SLE,which suggest that level IL-18 and sFas/sFasl may serve as an appropriate marker for evaluating SLE disease activity.IL-18 involved to Fas/FasL-mediated apoptosis, at least in part,in immune abnormalities and may possibly be involved in pathogenesis of SLE.

关 键 词：系统性红斑狼疮 SLE IL-18 可溶性sFas 可溶性sFas配体 细胞凋亡 

分 类 号：R593.241[医药卫生—内科学]