全反式维甲酸对大鼠腹主动脉球囊损伤后新生内膜形成和内皮再生的影响  

Effect of All-Trans Retinoic Acid on Reendothelialization and Neointima Formati on in Rat's Abdominal Artery with Balloon Withdrawal Injury

作　　者：党书毅[1] 王家宁[2] 王卫民[2] 黄永章[2] 张群林[1] 

机构地区：[1]附属太和医院心内科,湖北省十堰市442000 [2]分子生物学研究所,湖北省十堰市442000

出　　处：《中国动脉硬化杂志》2002年第1期16-18,共3页Chinese Journal of Arteriosclerosis

基　　金：湖北省科委基金 (991B2 8)资助。

摘　　要：为研究全反式维甲酸对球囊损伤的大鼠腹主动脉内皮再生和新生内膜形成的影响 ,制作球囊损伤的大鼠腹主动脉剥脱模型 ,将 12只血管损伤的Wistar大鼠随机分为两组 ,对照组 (n =6 )腹腔内注射脂肪乳剂 (1mL/d) ,全反式维甲酸组 (n =6 )腹腔内注射溶解于脂肪乳剂的全反式维甲酸 [4 μg/ (g·d) ],球囊损伤 14天后 ,采用原位灌注固定取材 ,染色 ,进行组织学观察和形态学分析。结果显示 ,全反式维甲酸组球囊损伤血管段的内皮再生面积大于对照组 ,而新生内膜形成面积小于对照组。结果提示 。Aim To investigate the effect of all trans retin oi c acid (ATRA) on reendothelialization and neointima formation in the rat's abdom inal artery after bal loon withdrawal injury. Methods The rat denuded ab dominal artery model with ba lloon withdrawal injury was performed. Twelve wistar rats were randomly assigne d to control group (intraperitoneal injection of 1 mL/d intralipid) and ATRA g roup [intraperitoneal injection of 4 μg/(g·d) ATRA] dissolved in intralipi d. After fourteen days balloon withdrawal injury in the situ perfusion fixa tion was performed with 10% formalin and the specimens were obtained. Histologi c observations and morphometric analysis were made. Results Reendothelialization area of arterial balloon injury increased in ATRA g roup compared with that in control group, while Neointima area is smaller in ATR A group than in c ontrol group. Conclusion ATRA has accelerated reendothelia lization and inhibited neointima formation of injuried vessels.

关 键 词：全反式维甲酸 血管内膜增生 血管内皮 经皮冠状动脉成形术 腹主动脉球囊损伤 术后再狭窄 内皮再生 新生内膜形成 

分 类 号：R654.206[医药卫生—外科学]