改进逆流分配法与逆流分配法程序计算结果比较  

Comparison of Counter-Current-Distribution before and after improvement

作　　者：王有生[1] 李建辉[1] 刘能德[1] 黄循明[1] 朱丹成[1] 杜道林[2] 

机构地区：[1]中国人民解放军第187医院天涯制药厂,海南海口571159 [2]海南师范学院生物系,海南海口571158

出　　处：《中国医院药学杂志》2002年第2期67-68,共2页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金资助项目 (No :396 6 0 0 18) ;海南省自然科学基金资助项目 (No :3990 8)

摘　　要：目的 :对改进逆流分配法及逆流分配法进行对比研究。方法 :分别对逆流分配法、改进逆流分配法设计电脑运算程序 ,以 3个三尖杉酯碱、高三尖杉酯碱混合物样品数据进入程序 ,统计三尖杉酯碱、高三尖杉酯碱分离率。结果 :改进逆流分配法工艺过程简化 ,分离率比逆流分配法提高 12 %～ 2 0 %。结论 :改进逆流分配法在工艺过程中及时收集起始端 (末端 )的三尖杉酯碱 (高三尖杉酶碱 ) ,在实际生产中简便易行。OBJECTIVE To compare the process of counter current distribution(CCD) and improved counter current distribution.METHODS The computer programs of CCD and improved CCD were designed,based on the isolation ratios of harringtonine and homoharringtonine in the programs of CCD and improved CCD with three samples containing harringtonine and homoharringtonine, the calculation in the programs of CCD and improved CCD were studied.RESULTS The process of improved CCD was simpler than that of CCD and the isolation ratios of harringtonine and homoharringtonine in the program of improved CCD were higher (about 12%～20%) than those in CCD.

关 键 词：逆流分配法 改进逆流分配法 程序计算结果 比较 药物分离 

分 类 号：TQ460.1[化学工程—制药化工]