褪黑素的体外经皮扩散试验及其滞留时间法的评价  

Evaluation of percutaneous lag time method for melatonin

作　　者：齐瑗晶[1] 赵子彦[1] 薛克亮[1] 李惠金[1] 栾杨[1] 孟晓东[1] 

机构地区：[1]山东省医学科学院药物研究所,山东济南250062

出　　处：《中国医院药学杂志》2002年第2期72-73,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :用滞留时间法评价所得褪黑素的经皮渗透参数 ,并根据所得参数推断褪黑素能否制成经皮给药制剂。方法 :用 6个扩散池进行褪黑素体外 2 4h的经皮扩散试验 ,并计算出褪黑素的扩散系数D、分配系数Km、稳态通量Jss等参数。用滞留时间法将这些参数进行了验证。结果 :证明所得参数基本正确。结论 :褪黑素完全可以制成体外经皮给药制剂。OBJECTIVE To evaluate parameters of percutaneous for Melatonin TTS.METHODS Percutaneous permeation of melatonin was studied in 24 hours in vitro. The diffusion coefficient ( D ), partition coefficient ( K m) and steady state flux ( J ss ) were gotten.RESULTS The results indicated that these coefficients were obtained.CONCLUSIONS Melatonin can be designed for TTS absolutely.

关 键 词：褪黑素 经皮扩散 滞留时间法 评价 经皮给药剂型 

分 类 号：R977.1[医药卫生—药品] R944.9[医药卫生—药学]