双氯芬酸钠缓释微丸的制备及体外释放度  

Preparation and drug release study of diclofenac sodium sustained release micropellets

作　　者：林宁[1] 肖学成[1] 饶泽萍[1] 丁广林[1] 

机构地区：[1]湖北药检高等专科学校,湖北武汉430064

出　　处：《中国医院药学杂志》2002年第2期85-87,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :制备双氯芬酸钠缓释微丸 (DS SRMP)并研究其体外释药性能。方法 :选用乙基纤维素等辅料为阻滞剂制备了DS SRMP ,并采用紫外分光光度法进行了体外释放度的研究。结果 :实验研究表明DS SRMP体外释药符合零级动力学过程 ,Kr0 =8.78%·h-1(t≤ 8h)。结论 :DS SRMP具有较好的释药性能 ,为一种较理想的口服缓释剂型。OBJECTIVE To prepare diclofence sodium sustained release micropellets (DS SRMP) and study its releasing characteristics.METHODS Ethyl cellulose was used to prepare the DS SRMP. UV method was established for assaying release rates of DS SRMP in vitro.RESULTS The release mechanism of DS SRMP in vitro may be described by apparent zero order kinetics, Kr 0= 8.78% ·h -1 (t≤8h).CONCLUSIONS The study indicats that DS-SRMP had better sustained release effect.

关 键 词：双氯芬酸钠 缓释微丸 体外释放度 DS-SPMP 

分 类 号：R971.1[医药卫生—药品] R944.9[医药卫生—药学]