红毛五加多糖对四氧化碳肝损伤保护作用机理探讨  

Studies on the mechanism of protective action of Acanthopanax giraldii Harms polysccharides on CCl_4 injured liver in rats

作　　者：党月兰[1] 李淑玉[1] 

机构地区：[1]兰州医学院药理教研室,兰州730000

出　　处：《中药药理与临床》2002年第1期7-8,共2页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的 :研究红毛五加多糖 (AGP)对四氯化碳 (CCl4 )肝损伤保护作用机理。方法 :采用大鼠CCl4 肝损伤模型进行实验。结果 :AGP能明显降低CCl4 肝损伤大鼠的肝MDA ,提高肝GSH和细胞色素P 45 0含量及GSH Px活性。结论 :AGP对CCl4 引起的急性肝损伤保护作用机制可能与其清除自由基、抑制脂质过氧化及诱导肝药酶有关。Object: To study the mechanism of protective action of Acanthopanax giraldii Harms (AGP) on CCl 4 injured liver in rats. Methods: The injured liver model induced by injection CCl 4 in rats. Results: AGP inhibited the rise of hepatic MDA content, elevated the decline of hepatic GSH and GSH Px levels and hepatocyte microsomal cytochrome P450 in CCl 4 intoxicated rats. Conclusion: The mechanism of protective action of AGP on CCl 4 injured liver is related to the clearing of free radicals and inhibition of lipid peroxidation.

关 键 词：红毛五加多糖 四氧化碳 肝损伤 脂质过氧化 细胞色素P-450 作用机理 

分 类 号：R285.5[医药卫生—中药学]