生殖激素控制卵泡细胞凋亡的研究进展  

The Advance on Apoptosis Regulated by Hormones in Ovarian Follicles

作　　者：杨世华[1] 余四九[1] 

机构地区：[1]甘肃农业大学动物医学院,甘肃兰州730070

出　　处：《动物医学进展》2002年第2期1-5,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金资助项目 (39970 5 4 6 )

摘　　要：研究表明颗粒细胞凋亡是导致卵泡闭锁的重要原因 ,而颗粒细胞凋亡涉及许多因素 ,其中生殖激素 ,如 Gn RH、FSH、LH、P4 、E、A、GH、Mel、inhibin、activin、follistatin等间接地和直接地对卵巢卵泡细胞凋亡发挥重要的综合控制作用 ,因此正确理解激素对体内。Current data demonstrate that the apoptosis of ovarian granulosa cells is a main reason of follicular atresia. Granulosa cells apoptosis related to many factors, but hormones, such as GnRH,FSH,LH,P 4,E,A,GH,Mel,inhibin,activin and follistatin,can directly or indirectly control apoptosis in follicular atresia, which acts as the important mechanism in development and atresia of ovarian follicles. Herein,correctly understanding the regulation network of hormones on follicles atresia and apoptosis of granulosa cells in vivo or in vitro plays the very important theoretic and practical roles.

关 键 词：生殖激素 卵泡颗粒细胞 细胞凋亡 哺乳动物 

分 类 号：Q492.5[生物学—生理学] S814.1[农业科学—畜牧学]