含氮羧酸的羟乙基甲硝唑酯的合成  

Synthesis of Some Esters of Acids Containing Nitrogen with Metronidazole

作　　者：赵宪瑞[1] 李崇熙[1] 

机构地区：[1]北京大学化学与分子工程学院,北京100871

出　　处：《北京大学学报（自然科学版）》2002年第2期175-180,共6页Acta Scientiarum Naturalium Universitatis Pekinensis

摘　　要：为寻找羟乙基甲硝唑的替代物 ,分别采用酸酐法、酰氯法或DCC法 ,将氨基羧酸与羟乙基甲硝唑反应 ,得到 5个亲水性不同的单酯或二酯 ,用MS谱确证了次氨基三乙酸与乙酸酐反应的中间物 ,并对得到的酯的1H NMR谱进行了初步研究。 3个二酯中 ,有In order to find replacer for Metronidazole and drug selection.Some diesters or esters of acids containing nitrogen with Metronidazole were designed and synthesized,which have difference in water\|solubility.Metronidazole was reacted with the corresponding amino or imino multi\|carboxylic acid compounds in the presence of acetic anhydride or thionyl chloride or DCC.The intermediate of nitrilotriacetic acid with Ac\-2O was identified by Mass Spectrum.Out of three diesters two are novel.

关 键 词：羟乙基甲硝唑酯 α-氨基羧酸 氨基酸二酯 含氮羟酸 药物合成 抗生素药物 

分 类 号：TQ465[化学工程—制药化工]