ASS对实验性Ⅱ型糖尿病大鼠胰岛素和C肽分泌作用研究  

Study of ASS on insulin and C-peptide in experimental NIDDM rats

作　　者：李艳君[1] 濮继红 李艳萍[3] 杨杨[1] 姜吉文[1] 陈克功[1] 

机构地区：[1]黑龙江省佳木斯大学基础医学院解剖教研室,154002 [2]牡丹江市西安区妇幼保健院 [3]佳木斯市中心医院普外科

出　　处：《中国局解手术学杂志》2002年第1期21-22,共2页

摘　　要：目的 研究刺五加叶皂甙(ASS)对实验性Ⅱ型糖尿病大鼠胰岛素和C肽分泌作用影响。方法 应用放射免疫学方法对正常组和Ⅱ型糖尿病模型组大鼠(尾静脉注射链尿佐菌素25mg/kg加高脂、高热、高能量喂养)。在给予ASS后其空腹及口服葡萄糖后血浆中胰岛素和C肽变化测定。结果 ASS可增强Ⅱ型糖尿病大鼠胰岛素和C肽分泌,对正常大鼠无影响。结论 ASS可以促进Ⅱ型糖尿病大鼠胰岛素和C肽分泌。Objective To study the effects of ASS on insulin and C-peptide in experimental NIDDM rats. Methods Radioimmunoassay was used to measure the level of insulin and C-peptide in vein after giving ASS to normal rats and NIDDM rats, (to injected of STZ,25mg/kg. via tail vein and fed on diet of high fat and high calorie) . Results ASS could increase insulin and C-P secretion in NIDDM rats. Conclusion ASS can increase insulin and C-P secretion in NIDDM rats.

关 键 词：刺五加叶皂甙 Ⅱ型糖尿病大鼠 胰岛素 C肽 治疗 

分 类 号：R587.1[医药卫生—内分泌]