脚内核在电针镇痛及兴奋尾壳核镇痛中的作用  

Roles of entopeduncular nucleus in acupuncture analgesia and caudate-putamen nucleus stimulation-induced analgesia

作　　者：吴国冀[1] 陈正秋[1] 石宏[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《生理学报》2002年第1期55-59,共5页Acta Physiologica Sinica

摘　　要：用行为学和电生理学的方法 ,探讨脚内核在电针镇痛及兴奋尾壳核镇痛中的作用。脚内核微量注射红藻氨酸 7d后 ,电针对辐射热引起的大鼠缩腿潜伏期无明显影响 ,电针或兴奋尾壳核对丘脑束旁核神经元的伤害性反应亦无明显影响。与正常对照组电针或兴奋尾壳核产生的抑制作用相比有显著性差异 (P <0 .0 5 ) ;与脚内核微量注射生理盐水 7d后 ,电针可提高大鼠缩腿潜伏期 ,及电针或兴奋尾壳核对束旁核神经元伤害性反应的抑制作用相比 ,有显著性差异 (P <0 0 5 )。上述结果提示 。The present study was to investigate whether entopeduncular nucleus (EP) is involved in caudate putamen nucleus (CPu) stimulation induced analgesia and in acupuncture analgesia. It was found that the foot withdrawal latency elicited by radiant heat exposure was increased after electroacupuncture analgesia (EA), and the nociceptive responses of neurons in parafascicular nucleus (Pf) were inhibited after EA or after excitation of CPu neurons in normal rats, but the foot withdrawal latency and nociceptive responses of Pf neurons were unchanged by EA or excitation of CPu in the rats with lesion of EP by local application of kainic acid. The results obtained with microinjeciton of saline instead of kainic acid into the EP were the same with those in the nonlesioned control group. The differences in the results between the lesion group and the other groups were significant ( P <0 05). It is suggested that EP is involved in acupuncture analgesia and also plays an important role in caudate putamen nucleus stimulation induced analgesia.

关 键 词：脚内核 兴奋尾壳核 电针镇痛 机制 

分 类 号：R338.24[医药卫生—人体生理学]