壳聚糖用于降低固天泉胶囊得膏率的工艺研究  

Study on the Process of Chitosans Used for Reducing the Coefficient of Unguent in Gutianquan-Capsule

作　　者：郭胜伟[1] 王天山[1] 蔡宝昌[1] 

机构地区：[1]南京中医药大学新药指纹图谱开发研究工程中心,江苏南京210029

出　　处：《时珍国医国药》2002年第3期146-147,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的 :探讨壳聚糖澄清法替代乙醇沉淀法工艺的可行性及对浸膏得率的影响。方法 :比较乙醇沉淀法和壳聚糖澄清法所得到的浸膏得率及浸膏中人参皂苷 Rg1,Re的定性分析以及 Rg1、阿魏酸含量测定考察 ,并进行稳定性实验比较。结果 :乙醇沉淀法所得的浸膏得率为 17.2 % ,壳聚糖澄清法所得的浸膏得率为 12 .8% ,两法均能够较好地使水提液澄明 ,且后者还能够在降低浸膏得率 ,保留有效成分 ,保证制剂稳定性方面优于前者 ,并能缩短生产周期 ,降低成本。结论Objective:To study the influence of coefficient of unguent and feasibility of method of chitosans clarification replaing water extraction and alcohol precipitation method.Methods:Compare the coefficient of unguent of chitosans clarification method, water extraction and alcohol precipitation method, and qualitative assay of ginsenoside Rg 1, Re, and snide measurement of ginsenoside Rg 1, ferulic acid, and stability experiment.Results:The coefficient of unguent of water extraction and alcohol precipitation method was 17.2 %, of unguent of chitosans clarification method was 12.8%. They all could clarify liquor of water extraction.Conclusion:Chitosans clarification method can replace water extraction and alcohol precipitation method in process of Gutianquan Capsule.

关 键 词：壳聚糖 固天泉 得膏率 制备工艺 中药 

分 类 号：R283[医药卫生—中药学]