化学滴定法测定羟乙基β-环糊精的平均取代度  

Chemical Determination of Average Substitution Degree of Hydroxyethyl-β-Cyclodextrin

作　　者：郝爱友[1] 张立新[1] 张海光[1] 

机构地区：[1]山东大学化学与化工学院,济南250100

出　　处：《应用化学》2002年第3期301-303,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助课题 (2 990 2 0 0 4)

摘　　要：A chemical analytical method for quantitative determination in hydroxyethyl group of hydroxyethyl β cyclodextrin is proposed. The method consists of reacting hydroxyethyl β cyclodextrin with HI in the presence of catalyst on heating to form the corresponding amounts of ethene and iodoethane. Then react these compounds with bromine to give I 2, which can be easily determined by standard hyposulphite solution. The formulas for calculation of the average substitution degree from titration results are described. The results obtained by this method appeared to be more accurate than those based on 1H NMR method.A chemical analytical method for quantitative determination in hydroxyethyl group of hydroxyethyl β cyclodextrin is proposed. The method consists of reacting hydroxyethyl β cyclodextrin with HI in the presence of catalyst on heating to form the corresponding amounts of ethene and iodoethane. Then react these compounds with bromine to give I 2, which can be easily determined by standard hyposulphite solution. The formulas for calculation of the average substitution degree from titration results are described. The results obtained by this method appeared to be more accurate than those based on 1H NMR method.

关 键 词：羟乙基β-环糊精 平均取代度 化学滴定 测定 平均分子量 

分 类 号：O636.1[理学—高分子化学]