β-三芳基锗-α(β)-取代丙酸同1-乙氧基锡杂噁唑烷的反应  

The Reaction of β-Trialkylgermanium-α (β)-substituted Propionic Acid with 1-Ethoxystannatrane

作　　者：宋雪清[1] 罗宁 孙丽娟[1] 谢庆兰[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室,天津300071 [2]重庆市经济委员会安全生产局,重庆400015

出　　处：《化学学报》2002年第2期338-342,共5页Acta Chimica Sinica

基　　金：国家自然科学基金 (No .2 0 0 72 0 19)资助项目

摘　　要：利用 β 三芳基锗 α(β) 取代丙酸同 1 乙氧基锡杂唑烷的 1 位取代反应 ,合成了 15个 1 [(β 三芳基锡 α(β) 丙酰氧基 ] 2 ,8,9 三氧杂 5 氮杂 1 锡杂三环 [3,3,3,0 1 5]十一烷 ,并研究该反应规律 ,利用IR ,NMR和MS表征了该类化合物的结构和质谱裂解机制 .生物活性测定表明 ,它们只对某些细菌如溶血链球菌和金黄葡萄糖球菌有较好的抑制作用 .The reaction of β-trialkylgermium-α(β)-substituted propionic acid with 1-ethoxystannatrane was studied and fifteen organometallic compounds containing germanium and tin were synthesized. The procedure of this reaction was described. The structures of prepared compounds were characterized by means of IR, NMR( 1H, 119Sn) and MS. The fragmentation mechanism of MS was proposed. The tests of biological activity showed that they have better inhibition activity only for some bacteria such as Beta hemolytic strepto coai and Staphylococus aureus.

关 键 词：三芳基锗 结构表征 杀菌活性 1-2氧基锡杂恶唑烷 取代丙酸 1-位聚代反应 

分 类 号：O626[理学—有机化学]