热分析法对固体药物氯苄律定的热分解过程研究  

Thermal Analysis of the Thermal Decomposition of Chlorobenzylidine

作　　者：李忠红[1] 倪坤仪[2] 周帼雄[1] 张灿[2] 黄文龙[2] 

机构地区：[1]江苏省药品检验所,南京210008 [2]中国药科大学,南京210009

出　　处：《药物分析杂志》2002年第2期105-109,共5页Chinese Journal of Pharmaceutical Analysis

基　　金：江苏省自然科学基金BK99101

摘　　要：目的:分析固体药物氯苄律定的热分解过程。方法与结果:采用热重分析与差示扫描量热分析2种方法研究了固体药物氯苄律定的分解动力学,求出其热解动力学参数活化能E;并结合红外光谱、核磁共振、粉末X射线衍射和高效液相色谱研究其热分解过程,推断其主要分解产物结构。结论:用热分析法研究固体药物氯苄律定的热分解过程,方法简便,结果可靠。Objective:To study the thermal decomposition of chlorobenzylidine. Method and Results: TG (thermogravimetry) and DSC ( differential scanning calorimetry) were used to study the decomposition kinetics of solid drug chlorobenzylidine, determine the thermal kinetic parameter energy of activation (E). IR, NMR, powder X -ray diffraction (PXRD) and HPLC were also used to study the thermal decomposition of the drug, determine the structure of principal decomposition products in thermal decomposition process. Conclusion: The method is simple and easy to do with reliable results.

关 键 词：热分析 氯苄律定 热分解过程 固定药物 研究 抗心律失常药 

分 类 号：R972.2[医药卫生—药品]