原发性肾病综合征患者治疗前后血及尿IL-8、IL-13水平测定及其临床意义  

Levels of IL-8 and IL-3 in serum and urine of patients with nephritic syndrome and their clinical significance

作　　者：胡昭[1] 江蓓[1] 郭齐[1] 时庆[1] 李爱菊[1] 岳少恒[1] 李宪花[1] 杨向东[1] 

机构地区：[1]山东大学齐鲁医院肾内科

出　　处：《山东医科大学学报》2002年第1期70-71,共2页Acta Academiae Medicinae Shandong

摘　　要：目的：探讨肾病综合征患者治疗前后血清及尿中ＩＬ－８、ＩＬ－１３水平变化及其临床意义。方法：采用ＥＬＩＳＡ法测定２５例肾病综合征患者血清及尿中ＩＬ－８、ＩＬ－１３水平并与正常对照进行比较。口服强地松（１ｍｇ／ｋｇ）８～１２ｗ后再次测定血清及尿中ＩＬ－８、ＩＬ－１３水平并与治疗前相比较。结果：治疗前血清、尿ＩＬ－８水平〔（３１．０８±３．０７）ｐｇ／ｍｌ、（４６．２２±１．８３）ｐｇ／ｍｌ〕较正常对照〔（２２．９９±２．２９）ｐｇ／ｍｌ、（２４．６１±１．０４）ｐｇ／ｍｌ〕显著升高（Ｐ＜０．０５），血清、尿ＩＬ－１３水平〔（３１．０５±２．７１）ｐｇ／ｍｌ、（６５．８０±１２．５０）ｐｇ／ｍｌ〕较正常对照〔（２５．６１±２．５２）ｐｇ／ｍｌ、（５３．５±６．４１）ｐｇ／ｍｌ〕显著升高（Ｐ＜０．０５）。治疗后血清、尿ＩＬ－８水平〔（２３．０６±２．６０）ｐｇ／ｍｌ、（２５．８５±４．０１）ｐｇ／ｍｌ〕较治疗前显著降低（Ｐ＜０．０５），血清、尿ＩＬ－１３水平〔（２７．４０±７．０９）ｐｇ／ｍｌ、（５０．３１±１１．１３）ｐｇ／ｍｌ〕较治疗前显著降低（Ｐ＜０．０５），与正常对照无显著差异。结论：肾病综合征患者，血清及?Objective:To investigate the clinical significanc e of interleukin-8（IL-8）and IL-13 in patients with nephritic syndrome (NS). Methods:Twenty healt hy v olunteers and 25 patients with NS were included in this study.IL-8 and IL-13 levels of fasting serum and urine were evaluated by EILSA before treatment and a fter treatment with prednisone for 8～12 weeks.Results:Before treatm ent,both IL-8 and IL-13 levels of se rum and urine in the patients were significantly higher than those of the contro l;But after treatment, these levels were significa ntly lowered.Conclusion:Since The serum and urinal IL-8 and IL-13 levels in patients w ith NS are higher than in normal individuoal,IL-8 and IL-13 may be closely rel ated to NS.After treatme nt with prednisone,IL-8 and IL-13 levels are decreased.This change suggests that IL-8 and IL-13 levels can reflect the condition of disease.

关 键 词：原发性肾病综合征 白细胞介素8 白细胞介素13 酶联免疫吸附测定 临床意义 

分 类 号：R692[医药卫生—泌尿科学]