产超广谱β-内酰胺酶细菌的种类及耐药特性  

Types and drug resistance of extended-spectrum beta-lactamase producing bacteria

作　　者：苑广盈[1] 郑秀峰[1] 张倩[1] 张延芳[1] 刘安蓉[1] 

机构地区：[1]济南市第四人民医院

出　　处：《山东医科大学学报》2002年第1期83-84,共2页Acta Academiae Medicinae Shandong

摘　　要：目的：研究质粒介导的超广谱β内酰胺酶（ＥＳＢＬ）细菌的种类和耐药特性。方法：采用Ｅｔｅｓｔ法对可疑细菌行ＥＳＢＬ检测，用ＫＢ法做药物敏感试验，用ＷＨＯＮＥＴ４软件进行分析。结果：在８９０株革兰阴性杆菌中检出产ＥＳＢＬ菌４４株，　阳性率４．９％。对亚胺培南、呋喃妥因、阿米卡星、环丙沙星的敏感率分别为１００％、６８．２％、２９．５％、２５．０％。结论：产ＥＳＢＬ细菌分布广泛、阳性率高，易借助耐药质粒传播，具有较高的交叉耐药性和多重耐药性。Objective:To study the types and drug resistance of plasmid transferred exte nded spectrum beta lactamase (ESBL) producing bacteria.Methods:Etest was adopted to detect the suspicious ESBL isolates. Microbial sensitivi ty tests were carried out with K B ,and the results were analysed with WHONE4 software.Results:From 890 strains of Gram negative bacilli, 44 ESBL producing strains were detected with a positive rate of 4.9%. The sensitive rates of ESBL to imipenem, nitrofur antion, amikacin, ciprofloxacin were 100%,68.2%,29.5% and 25.0% respective ly.Conclusion:The ESBL producing bactera distribute broadly,are easy to detect and spread easily through resistant plasmid with high cross resistance and multi resistance

关 键 词：超广谱Β-内酰胺酶 细菌感染 微生物敏感性试验 种类 耐药特性 

分 类 号：R372[医药卫生—病原生物学] R978.11[医药卫生—基础医学]