中药路路通化学成分的研究  

CHEMICAL COMPOSITION OF FRUCTUS LIQUIDAMBARIS──LULUTONG

作　　者：李春[1] 孙玉茹[1] 孙有富[1] 

机构地区：[1]中国中医研究院中药研究所化学室,北京100700

出　　处：《药学学报》2002年第4期263-266,共4页Acta Pharmaceutica Sinica

摘　　要：目的　研究中药路路通 (Fructusliquidambaris)的化学成分。方法　用色谱法分离路路通的化学成分 ,根据理化性质和波谱数据鉴定其结构。结果　分离得到 11个化合物 ,分别鉴定为 :β 谷甾醇 ( 1) ,3 oxo 11α ,12α epoxyoleanan 2 8,13 β olide ( 2 ) ,3 oxo 12α hydroxy oleanan 2 8,13 β olide ( 3 ) ,3α acetoxyl 2 5 hydroxyolean 12 en 2 8 oicacid ( 4 ) ,齐墩果酸 ( 5 ) ,熊果酸 ( 6) ,胡萝卜苷 ( 7)桦木酮酸 ( 8) ,没食子酸 ( 9) ,正二十九烷 ( 10 ) ,正三十烷酸 ( 11)。结论　 4为新化合物 ,3为首次从天然产物中分离得到 ,5 ,6,7,9,10和 11为首次从路路通中分离得到。AIM To study the chemical composition in the fruits of Liquidambar formana Hance. METHODS Various column chromatographic techniques were used to separate and purify the constituents. Their physical and chemical properities and spectral data were measured for structural elucidation. RESULTS Eleven compounds were isolated and identified as β sitosterol (1), 3 oxo 11α,12α epoxyoleanan 28,13β olide (2), 3 oxo 12α hydroxy oleanan 28,13β olide (3), 3α acetyloxy 25 hydroxyolean 12 en 28 oic acid (4), oleanolic acid (5), ursolic acid (6), daucosterol (7), betulonic acid (8), gallic acid (9), nonacosane (10) and n triacontanoic acid (11). CONCLUSION Among the isolated constituents, compound 4 is new compound, compound 3 is firstly isolated from the natural product and compound 5, 6, 7, 9, 10 and 11 are isolated from LuLuTong for the first time.

关 键 词：路路通 三萜 3α-acetoxyl-25-hydroxyolean-12-en-28-oicacid 化学成分 中药 

分 类 号：R284.1[医药卫生—中药学]