黄海葵附生真菌Penicillium thomii的化学成分  

CHEMICAL CONSTITUENTS FROM MARINE FUNGUS PENICILLIUM THOMII

作　　者：蒋亭[1] 田黎[2] 郭爱华[1] 付宏征[1] 裴月湖[3] 林文翰[1] 

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室,北京100083 [2]国家海洋局第一海洋研究所生物活性物质重点实验室,山东青岛266003 [3]沈阳药科大学天然药物化学教研室,辽宁沈阳110015

出　　处：《药学学报》2002年第4期271-274,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 ( 40 1760 38;2 9932 0 30 ) .

摘　　要：目的　研究黄海葵 (anemone)附生真菌Penicilliumthomii的化学成分。方法　用各种色谱技术进行分离纯化 ,根据理化性质和波谱数据进行结构鉴定。结果　从黄海葵附生真菌Penicilliumthomii菌丝体中分离得到 5个化合物 ,分别为青霉酮A(I) ,对甲基苯甲酸 (II) ,1 O 十六碳烷酰 2 O ( 9 十八碳烯酰 ) 3 O ( 9,12 十八碳二烯酰 )甘油酯 (III) ,5α ,8α 环二氧 2 4 ζ 甲基胆甾 6,2 2 二烯 3 β 醇 (IV)和大黄素 (V)。 结论　青霉酮A(I)为新化合物 ,化合物II,III。AIM To investigate the bioactive constituents from the mycelium of Penicillium thomii . Which isolated from Anemone collected in Qingdao beach. METHODS The constituents were separated by using various chromatography and the structures were identified on the basis of extensive spectral analysis. RESULTS Five compounds, namely penicillixanthone A (I), p methylbenzolic acid (II), 1 O hexadecanoyl 2 O (9 octadecenoyl) 3 O (9,12 octadecadienoyl) glycerol (III), 5α,8α epidioxy 24ζ methylcholesta 6,22 dien 3β ol (IV) and 1,6,8 trihydroxyl 3 methyl 9,10 anthracenedione (V), were isolated from the mycelium of Penicillium thomii . CONCLUSION Penicillixanthone A is a new compound, while the others are isolated from Penicillium thomii for the first time.

关 键 词：真菌 青霉属 青霉Shan酮A 黄海葵 Penicillium-thomii 化学成分 中药 

分 类 号：R284.1[医药卫生—中药学]