正交设计-重复试验法优选抗抑郁胶囊提取工艺  

OPTIMIZING EXTRACTION PROCESS OF ANTI-BLUES CAPSULES ZOICH ORTHOGRONAL DESIGN-REPEAT EXPERIMENT METHOD

作　　者：吴俊萍[1] 姜少灏[1] 王淑芹[2] 任永欣[1] 康丽娟[1] 张红霞[1] 

机构地区：[1]河北医科大学制药厂,石家庄050017 [2]河北省邯郸市峰峰矿务局第二医院

出　　处：《河北医科大学学报》2002年第2期95-97,共3页Journal of Hebei Medical University

摘　　要：目的优选抗抑郁胶囊的提取工艺。方法采用正交实验法 ,以栀子甙的含量 (高效液相色谱法 )为指标 ,考察煎煮次数 (A) ,煎煮时间 (B) ,加水倍数 (C) ,药材粒度 (D)四因素对栀子甙含量的影响。结果本方最佳提取工艺为A3 B1C3 D2 。结论煎煮 3次 ,每次 1h ,加水 12倍 ,药材粒度选粗粉为好 。ObjectiveTo optimize the extraction process of anti blues capsules.MethodsThe study was carried out through orthogonal experimental design,using the content of gardenia (HPLC) as the guide,four factors of decoction times (A), decoction durition(B), the amount of adding water (C),medicinal materials granularity (D) were studied.ResultsThe opeimal conditions for the extraction were A 3B 1C 3D 2.ConclusionExtract three times, with 12 times of water for 1 hour will give the best yield.The most suitable fineness of the raw herbal material was coarse.

关 键 词：抗抑郁药 正交实验 重复实验 提取工艺 

分 类 号：TQ460.7[化学工程—制药化工] R971.43[医药卫生—药品]