鹿角治疗乳癖症的研究 Ⅱ.鹿角提取物抑制乳腺增生机制的研究  

Studies on therapeutic effect of antler on cystic hyperplasia of breast in the ratⅡ Studies on mechanism of inhibiting cystic hyperplasia

作　　者：周秋丽[1,2] 鲍海鹰[1,2] 张颖悟 刘永强[1,2] 王丽娟 王本祥[1,2] 

机构地区：[1]长春中医学院新药研究中心 [2]白求恩医科大学应用基础医学研究所

出　　处：《中药药理与临床》1998年第3期23-25,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：己烯雌酚所致乳腺增生大鼠ｉｇ和ｓｃ鹿角提取物对血中催乳素ｐｒｏｌａｃｔｉｎ（ＰＲＬ）升高有抑制作用，尤其皮下给药最为明显。角叉菜胶和己烯雌酚两种炎症模型都伴有血中ＰＲＬ含量的升高，鹿角提取物对其ＰＲＬ升高均有抑制作用。本文证明，鹿角提取物抑制ＰＲＬ升高的机制可能通过升高脑多巴胺（ＤＡ）含量。 The mechanism of antler extracts for cystic hyperplasia of breast in the rat was studied.It was found that the antler extracts showed significant inhibitory effect on prolactin (PRL) content increase in the serum induced by the chondrusin and hexestrol.This study determined that when the content of dopamine (DA) in the brain was enhanced,the density of PRL in the serum was down regulated.

关 键 词：鹿角 鹿角提取物 催乳素 多巴胺 乳癖症 乳腺增生 药理学 

分 类 号：R282.740.5[医药卫生—中药学] R271.44[医药卫生—中医学]