地黄煎剂消退L-甲状腺素诱发的大鼠心肌肥厚并抑制其升高的心、脑线粒体Ca^(2+),Mg^(2+)-ATP酶活力  

Rehmanniae Regresses the Cardiac Hypertrophy and the Elevated Activity of Rat Cardium and Cerebrum Mitochondria Ca 2+ ,Mg 2+ ATPase Induced by L Thyroxine

作　　者：陈丁丁[1] 戴德哉[1] 章涛 

机构地区：[1]中国药科大学药理研究室

出　　处：《中药药理与临床》1997年第4期27-28,共2页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：Ｌ甲状腺素４ｍｇ／ｋｇ·ｄ连续ｐｏ７ｄ诱发大鼠心肌肥厚和心、脑线粒体Ｃａ２＋，Ｍｇ２＋ＡＴＰ酶活力显著升高。经地黄４ｇ／ｋｇ·ｄｐｏ治疗３ｄ后，心肌肥厚及其心、脑升高的Ｃａ２＋，Ｍｇ２＋ＡＴＰ酶活力显著降低，但未恢复至正常。结论：地黄消退Ｌ甲状腺素诱发的大鼠缺血性心肌肥厚并抑制升高的心脑线粒体Ｃａ２＋，Ｍｇ２＋ＡＴＰ酶活力，保护心脑组织避免ＡＴＰ耗竭和缺血损伤。The cardiac hypertrophy and elevated activity of cardiac and cerebral mitochondia Ca 2+ ,Mg 2+ ATP was induced by L thyroxine 4mg/kg·d po for 7d in rat. After treatment of Radix Rehmanniae 4g/kg·d po for 3d, the cardiac hypertrophy and elevated activity of the cardiac and cerebral Ca 2+ ,Mg 2+ ATP was signficantly reduced respectively, but not to normal level. Conclusion:Radix Rehmanniae could prevent cardium and cerebrum from ATP depletion and ischemic injury by regression cardiac hypertrophy and supression elevated activity of cardiac and cerebral mitochondia Ca 2+ ,Mg 2+ ATPase induced by L thyroxine in rat.

关 键 词：L-甲状腺素 地黄 地黄煎剂 线粒体 CA^2+ MG^2+-ATP酶 心肌肥厚 缺血损伤 

分 类 号：R282.710.5[医药卫生—中药学] R259.422[医药卫生—中医学]