西洋参茎叶总皂甙毒理学研究  

Toxicologic study on Panax Quinquefolius Saponin

作　　者：徐惠波[1] 孙晓波[1] 周继胡[1] 温富春[1] 丁涛[1] 魏菲[2] 孙利雯 

机构地区：[1]吉林省中医中药研究院 [2]长春中医学院,长春130021

出　　处：《中药药理与临床》1999年第6期24-26,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：西洋参茎叶总皂甙(PNS) 小鼠iv LD50 为352-5 ±17-5 mg/kg ;一日内ig 的最大耐受量≥30g/kg 。以1-5 、0-75g/kg 剂量给大鼠ig 60 天,对动物生长、血常规、肝、肾功能及主要脏器无明显影响;以2-0 、1-0g/kg剂量给犬口服60 天,心电图、血液学。The LD 50 of Panax Quinquefolius Saponin (PNS) is 352.5±17.56mg/kg iv and maximal tolerance dose is ≥30g/kg ig ig in a days in mice. PNS 1.5g/kg and 0.75g/kg for 60d doesn't influence the growth, blood routine examinations, liver function, renal function and main organs of rats. In addition, it ig 2.0g/kg and 1.0g/kg for 60d doesn't change significantly ECG, hematological examinations, hematiological biochemical criterins and main organs in dogs.

关 键 词：西洋参茎叶总皂甙 毒理学 西洋参 心电图 血液生化学 

分 类 号：R282.710.5[医药卫生—中药学]