白虎追风丸对佐剂性关节炎大鼠滑膜细胞分泌TNF-α的影响  

Effect of Baihuzhuifengwan on TNF-α by Synoviocyte in Adjuvant Arthritis Rats

作　　者：施旭光[1] 张声鹏[1] 徐志东[1] 

机构地区：[1]广州中医药大学方剂教研室,广州510405

出　　处：《中药药理与临床》2000年第4期4-6,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：广东省中医药管理局资助!课题 (No 970 33)

摘　　要：目的 :研究白虎追风丸对佐剂性关节炎 (AA)大鼠滑膜细胞分泌肿瘤坏死因子 α(TNF α)的影响。方法 :采用消化分离的方法获得滑膜细胞 ,放免法检测原代大鼠滑膜细胞培养上清液中TNF α的水平。结果 :白虎追风丸可明显下调AA大鼠滑膜细胞分泌TNF α的水平。Objective: To study the effect of Baihuzhuifengwan (BHZFW) on the TNF-α secretion by synoviocytes in adjuvant arthritis (AA) rats. Methods: Synovium of knee joints from AA rats were digested by collagenase and tripsin to prepare DSSC (digested synovial single cells). The content of the supernatant fluid were assayed by the radioimmunoassay. Results: BHZFW down-regulated TNF-α productions of DSSC.

关 键 词：白虎追风丸 传剂性关节炎 AA 肿瘤坏死因子 消化分离 滑膜细胞 药理学 

分 类 号：R285.5[医药卫生—中药学]