纳洛酮对急性颅脑损伤治疗作用的临床观察  

The clinical study on acute brain injury treated by Naloxone therapy

作　　者：缪建平[1] 祝鸣兰[1] 慎建玉[1] 石柏仙[1] 陈爱琴[1] 

机构地区：[1]浙江大学医学院附属第二医院神经外科,杭州310009

出　　处：《中华急诊医学杂志》2002年第1期43-44,共2页Chinese Journal of Emergency Medicine

摘　　要：目的　观察研究纳洛酮对急性颅脑损伤的治疗作用。方法　①随机将急性颅脑损伤患者分为纳洛酮治疗组 (治疗组 )和常规治疗组 (对照组 ) ,各 40例。前者在颅脑伤后 12h以内 ,以常规治疗为基础 ,再给予纳洛酮 12～ 16mg ,静脉滴注 ,2 4h维持 ,连续 3d后 ,剂量改为 4 8mg ,连续 7d ,10d为一个疗程。②根据GOS评估 ,观察两组患者病情预后和血浆 β -内啡肽不同时间的含量变化。 结果　重型颅脑损伤 (GCS3～ 8分 )者 ,治疗组预后好于对照组 (P <0 0 5 ) ;治疗组用纳洛酮后血浆β -内啡肽均值较对照组下降明显 (P <0 0 1)。结论　急性颅脑损伤早期应用纳洛酮 ,可使颅脑伤后的病残程度降低和治疗效果提高。Objective To study the therapeutic effect of Naloxone(NLX)on acute brain injury.Methods ①The eighty patients with acute brain injury were randomly divided in two groups,each with 40 patients.Both groups received routine therapy(medication and/or operation).NLX group received NLX 16～20 mg/d in 480ml normal saline intravenously at a slow rate(20ml/h).From day 4 to day 10,NLX 4 8mg/d was administrated by the same method.②The content of blood β-EP was measured before and after treatment in both groups.Results ①In severe brain injury the cure rate 69 2%(18/26)in NLX group was higher than that 40%(10/25)in control group,with morbility of both groups were 7 69% and 24 0%,and mortality 3 85% and 16% respectively(P<0 05).②Blood β-EP content in NLX group was significantly decreased campared with that of the control group(P<0 01).Conclusion The effect of patients with acute brain injury can be improved by early administration NLX.

关 键 词：急性颅脑损伤 纳洛酮 药物治疗 

分 类 号：R651.15[医药卫生—外科学]