卡维地洛治疗急性心肌梗死与及其抗氧自由基的临床研究  

Clinical investigations of carvedilol treatment on patients with acute myocardial infarction and its function of antioxygen free radical

作　　者：林玲[1] 黄春涛[1] 石延科[1] 苗云波[1] 马德林[2] 

机构地区：[1]云南省第一人民医院心内科,昆明650032 [2]云南省第一人民医院放射免疫科

出　　处：《临床心血管病杂志》2002年第3期120-121,共2页Journal of Clinical Cardiology

摘　　要：目的 :研究卡维地洛治疗急性心肌梗死 (AMI)及其抗氧自由基 (OFR)的作用。方法 :4 4例AMI患者随机分成治疗组 (2 3例 ) ,对照组 (2 1例 ) ,两组在治疗相同的基础上 ,治疗组加服卡维地洛片 ,每次 10～ 2 0mg ,每日 2次。服药 4 8h后抽血查血清丙二醛 (MDA)含量 ,做心电图、2 4h动态心电图。并在 2周病情稳定后进行超声心动图检查 ,观察两组患者的心率、心律失常发生率及左室射血分数 (LVEF)。结果 :治疗组MDA含量低于对照组 (P <0 .0 5 ) ,心率、心律失常发生率明显低于对照组 (P <0 .0 1) ;而LVEF高于对照组 (P <0 .0 5 )。结论 :卡维地洛具有抗氧化性质 ,能有效地清除AMI时OFR ,降低心律失常发生 ,促进心功能恢复 ,是治疗AMI的理想药物。Objective:To study the clinical efficacy of carvedilol treatment on patients with acute myocardial infarction (AMI) and its function of antioxygen free radical.Method: Forty four patients with AMI were randomized to take carvedilol(10～20 mg bid , n=23) and control group(n=21)on the basis of conventional treatment. Venous blood samples were obtained after 48 hours to examine the serial change of the level of serum malondialdethyde (MDA). ECG and 24-hour dynamic electrocardiograph were performed. Heart rate, the ratio of cardiac arrhythmia and left ventricular ejection fraction (LVEF) were assessed by echocardiography during two weeks. Result: Compared with that in the control group, the level of serum MDA decreased in patients with AMI undergoing carvedilol treatment(P< 0.05). Heart rate and the ratio of cardiac arrhythmia of treatment group were obviously lower than those of control group(P< 0.01). And the LVEF in the latter was still higher than that of the former(P< 0.01). Conclusion: Carvedilol has antioxygen property. It can clear oxygen free radical(OFR), decrease ratio of cardiac arrhythmia and improve restoration of heart function. Carvedilol is an effective and safe agent in treatment on patients with AMI.

关 键 词：急性心肌梗死 抗氧自由基 卡维地洛 药物治疗 

分 类 号：R542.22[医药卫生—心血管疾病]