米索前列醇用于足月妊娠计划分娩的方法探讨  

Approaches to administration of misoprostol in inducing the planned labor for full-term pregnancy

作　　者：周玉玲[1] 田巧花 李罗珍[1] 姜海燕[1] 

机构地区：[1]解放军252医院,河北保定071000 [2]濮阳市妇幼保健院,河南濮阳457000

出　　处：《华北国防医药》2002年第1期21-23,共3页Medical Journal of Beijing Military Region

摘　　要：目的 探讨米索前列醇(米索)用于足月妊娠计划分娩的适宜给药方法。方法 将符合试验条件的足月妊娠初产妇134例随机分为三组:A组36例,单用米索50μg口服,每3小时1次,直至临产;B组50例,单用米索50ug阴道用药,每3小时1次,直至临产;C组48例,采用米索50μg口服加阴道用药,首次于晨5时口服,8时阴道放置,以后每3小时阴道放置1次,直至临产。三组一日最大剂量均为200μg。结果 ①引产结果:引产成功率、引产成功者阴道分娩率、产后2小时出血量、新生儿体重三组间比较无统计学差异(P>0.05);经阴道分娩者,产程进入活跃期后宫缩不满意,需加用缩宫素静脉滴注促进宫缩的比率,A组明显高于B、C两组,差异具有显著统计学意义(P<0.05);②阴道分娩情况:A组第一产程、引产时间均明显长于B、C两组,第一产程差异具有极显著性(P<0.001),引产时间的差异也具有显著的统计学意义(P<0.05)。③不良反应:A组产程中宫缩不协调的发生率较高,因为个别病例未进行统计,A组羊水粪染率较高,而三组胎儿窘迫及新生儿窒息发生率之间的差异无统计学意义(P>0.05)。结论 米索前列醇用于足月妊娠计划分娩,采用50μg晨5时首次口服,后每3小时1次阴道给药方法,引产时间短、不良反应小、分娩过程结束早,是一种值得推广的用药方法。Objective To explore the acceptabl administration plan of misoprostol in order to induce planned labor for full-term pregnancy. Methods 134 primiparas at term pregnancy with inclusion criteria were devided randomly into three groups. 36 subjects in the group A took orally misoprostol 50 ?g every 3 hours; 50 parturients in group B received vaginal use of misoprostol 50 ?g every 3 hours; 48 women in group C took orally 50 ?g misoprostol plus vaginal administration, firstly 50 ?g was taken orally at five oclock in the morning,and then 50 ?g was given vaginally 3 hours later. Afterwards vaginal use was repeated every 3 hours. All the subjects received the drug constantly until the onset of labor and the largest dosage for each woman was 200 ?g per day. Results `$The results of induction: There were no statistical differences in the successful! rate of labor induction, vaginal delivery rate,postpartura hemorrhage within 2 hours, the neonatal weight among the three groups(P >0. 05). For vaginal delivery, the incidence of inefficient uterine contraction and oxytocin administration at actic phase in group A was greatly higher than those in group B and C with a significant defference(P < 0. 05) ; a$Vaginal delivery; The first stage of labor and induction in group A took significantly longer time than that in group B and C; there was a very significantly difference in the first stages of labor(P <0. 001) , and a statistically difference in the induction process (P < 0. 05) , but that was no statistical difference between group B and group C; b$Side effect: There was a higher incidence of irregular uterine contraction in stages of labor and a higher incidence of amniotic fluid contamination with meconium in group A. The differences in fetal distress and neonatal asphyxia were not statistically significanta-mong the three groups (P > Q. 05). Conclusions It was worth popularizing that 50 ?g misoprostol was given to induce the planned labor for full-term pregnancy, that is, firstly 50?g was taken orally at five oclock in the m

关 键 词：米索前列醇 正常分娩 阴道内投药 口服投药 计划分娩 足月妊娠 药物不良反应 

分 类 号：R984[医药卫生—药品] R714.3[医药卫生—药学]