多孔双相HA/TCP和HA在模拟人体体液中类骨磷灰石的形成  

Formation of Bone-like Apatite on HA and/or Porous HA/TCP in A Flowing Simulated Body Fluid

作　　者：段友容[1] 刘科伟[1] 陈继镛[1] 张兴栋[1] 

机构地区：[1]四川大学生物材料工程研究中心,四川成都610064

出　　处：《四川大学学报（工程科学版）》2002年第2期44-47,共4页Journal of Sichuan University (Engineering Science Edition)

基　　金：国家重大基础研究项目 (973 );生物医学材料的基础科学问题研究 (G19990 64 760 )资助项目

摘　　要：利用模拟人体体液 (SimulatedBodyFluid ,SBF)流动装置 ,研究SBF在人体肌肉组织流率情况下多孔羟基磷灰石 /磷酸三钙 (HA/TCP)和羟基磷灰石 (HA)陶瓷表面和孔壁类骨磷灰石形成。结果表明 :材料在以生理流率的SBF浸泡 14d后 ,HA/TCP仅在多孔陶瓷孔隙内部形成类骨磷灰石 ;HA表面和孔隙内壁都未形成类骨磷灰石。如果增加SBF中的Ca2 + 、HPO42 -的浓度 ,则在孔隙内壁有类骨磷灰石形成。材料在静态SBF中浸泡 ,HA/TCP多孔材料孔壁观察到晶状沉积物 ;The formation of bone like apatite on the surface of hydroxy apatite (HA) inside SBF of flowing at physiological rate was investigated compared with hydroxyapatite/tricalcium phosphate (HA/TCP) ceramics. The results of a 14 day immersion of samples in static SBF showed that the formation of bone like apatite was occurred both on the surface and in the wall of the pores of materials. When SBF flowed at the physiological rate of the tissue fluid in muscle (2?ml/(100?ml·min)), bone like apatite can be detected only in the wall of the pores of the materials. There was no bone like apatite formation on both in the pores and on the surface of the HA when SBF flowed at rate 2?ml/(100?ml·min). By increasing the concentration of Ca 2+ and HPO 4 2- in SBF to 1.5 fold of the standard SBF, a 7 day immersion experiment result showed that bone like apatite could be found in the pore of the materials.

关 键 词：多孔磷酸钙陶瓷 SBF 类骨磷灰石 人体体液 诱导骨 羟基磷灰石 HA/TCP HA 模拟 

分 类 号：R318[医药卫生—生物医学工程] R336[医药卫生—基础医学]