葡醛内酯对小鼠对乙酰氨基酚代谢及其所致肝损害的影响  

Effect of glucurolactone on metabolism of acetaminophen and its liver impairment in mice

作　　者：刘志红[1] 孙晓莉[2] 南鹏娟[2] 

机构地区：[1]第四军医大学唐都医院药学部,陕西西安710038 [2]第四军医大学基础部化学教研室,陕西西安710033

出　　处：《第四军医大学学报》2002年第4期322-323,共2页Journal of the Fourth Military Medical University

摘　　要：目的　研究葡醛内酯对昆明种小鼠对乙酰氨基酚代谢影响及对对乙酰氨基酚所致的肝损害有无保护作用 .方法　给昆明种小鼠 ip 1 50 mg· kg-1 对乙酰氨基酚及葡醛内酯观察小鼠对乙酰氨基酚代谢速率的改变 .用诱导给药及同时给药法 ip与对乙酰氨基酚等剂量的葡醛内酯观察对对乙酰氨基酚所致的肝损害的影响 .结果　葡醛内酯对昆明种小鼠对乙酰氨基酚代谢无影响 ,对对乙酰氨基酚所致的肝损害也无保护作用 .AIM To study the effect of glucurolactone on metabolism of acetaminophen and whether there is protective effect on liver impairment induced by acetaminophen. METHODS After ip 150 mg·kg -1 acetaminophen and glucurolactone simultaneously, the variation of metabolic ratio was determined. The effect of liver impairment induced by acetaminophen was observed while acetaminophen and glucurolactone were administered ip with inducing or simultane ous administering methods. RESULTS Glucurolactone had no effect on metabolism of acetaminophen and no protecting action on liver impairment induced by acetaminophen in Kunming mice. CONCLUSION Glucurolactone has no direct detoxification to the toxicity induced by acetaminophen in mice.

关 键 词：葡醛内酯 醋氨酚 肝疾病 化学诱导 代谢 乙酰氨基酚 

分 类 号：R963[医药卫生—微生物与生化药学]