三氟化硼乙醚无溶剂催化合成二苯甲酮衍生物  

Synthesis of Benzophenone Derivatives by Solvent-Free Catalytic of Boron Trifluoride Ether

作　　者：周明 黄年玉 刘明国 Zhou Ming;Huang Nianyu;Liu Mingguo(College of Biological&Pharmaceutical Sciences,China Three Gorges Univ.,Yichang 443002,China)

机构地区：[1]三峡大学生物与制药学院,湖北宜昌443002

出　　处：《三峡大学学报（自然科学版）》2018年第6期97-100,共4页Journal of China Three Gorges University：Natural Sciences

基　　金：国家自然科学基金项目(21272136)

摘　　要：以苯甲酸和间苯二酚为原料,Lewis酸三氟化硼乙醚催化、无溶剂的条件下可高效合成二苯甲酮.通过对反应条件的筛选,发现0.4倍当量的催化剂、反应温度110℃、反应时间25min为最佳反应条件,产物收率可达90%;且副产物为水,实现了二苯甲酮衍生物的绿色合成.Diphenylketone is synthesized with benzoic acid and resorcinol as the raw material,catalyzed by Lewis acid trifluoride ether in solvent-free condition.Through the selection of reaction conditions,it is discovered that the best reaction conditions is 0.4 times the equivalent of catalyst at 110℃ with the reaction time of25 min;the yield can reach 90%.For the byproduct is water,the green synthesis of diphenylketone derivatives is realized.

关 键 词：二苯甲酮 三氟化硼乙醚 合成 

分 类 号：O621.3[理学—有机化学]