干扰素在猪黏膜免疫应答中的研究进展  

Overview on interferon in the mucosa immune response of pig mucosal immunity

作　　者：刘丽蓉 侯力丹[3] 王萌 刘文军[1,2] 李晶 LIU Lirong;HOU Lidan;WANG Meng;LIU Wenjun;LI Jing(CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100049,China;Department of viral biologics,China Institute of Veterinary Drug Control,Beijing 100081,China)

机构地区：[1]中国科学院微生物研究所,病原微生物与免疫学重点实验室,北京100101 [2]中国科学院大学存济医学院,北京100049 [3]中国兽医药品监察所病毒制品检测室,北京100081

出　　处：《科技导报》2018年第21期109-115,共7页Science & Technology Review

基　　金：国家重点研发计划资助项目(2017YFD051105)

摘　　要：黏膜免疫系统是动物产生免疫应答的物质基础,参与机体免疫应答并发挥着重要的功能。猪群接种免疫疫苗后,疫苗经黏膜免疫系统可产生黏膜抗体并激活全身性免疫应答,干扰素参与早期黏膜免疫,具有抗病毒及免疫调节等多种生物学功能。从不同种类的猪干扰素和免疫系统的相关性角度出发,阐述猪干扰素对黏膜免疫的调节作用。重点综述了干扰素与黏膜免疫系统、猪干扰素对免疫系统的调节作用及干扰素作为黏膜免疫佐剂的研究现状,旨在为猪干扰素作为黏膜免疫佐剂的研制提供参考。The animal mucosal immune system serves as the material basis of the immune response,and plays an important role.The vaccine is induced by the mucosial antibody derived from the mucosal immune system,followed by the activated systemic immune response. The interferon acts as a potential mucosal immune adjuvant involved in many biological functions,such as antivirus and immune regulation. This paper reviews the correlation between the mucosal innate immunity and the porcine interferon,focusing on the immunomodulatory roles of the mucosal immune system;the porcine interferon signaling pathway and the immunologic adjuvant,to provide a reference for the development of the porcine interferon as a mucosal immune adjuvant.

关 键 词：黏膜免疫系统 猪干扰素 免疫佐剂 免疫调节 

分 类 号：S852.4[农业科学—基础兽医学]