Klotho基因调控生长轴GH-IGF1及相关研究进展  

Relationship between Klotho gene and growth axis GH-IGF1

作　　者：黎萍(综述)[1] 曾繁杰(综述)[1] 邢杰(审校)[1] Li Ping;Zeng Fanjie;Xing Jie(Department of Developmental Pediatrics,the Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院发育儿科,130041

出　　处：《国际儿科学杂志》2018年第11期869-871,876,共4页International Journal of Pediatrics

基　　金：吉林省卫计委青年科研课题(2015Q007);吉林大学白求恩医学部青年基金(2015026021);金磊儿科内分泌中青年医师成长科研基金(PEGRF201607001)

摘　　要：Klotho是一种抗衰老基因,主要在肾脏和脑组织中表达。Klotho表达受多种因素调控,Klotho蛋白可通过膜受体和类激素方式发挥钙磷及能量代谢调控、心血管系统和肾脏保护、抗衰老等作用。新近研究表明,Klotho与生长激素(GH)-胰岛素样生长因子1(IGF1)轴密切关联、互相调控,一方面GH-IGF1轴可上调Klotho水平,而后者又可以抑制外周IGF1分泌;另一方面,Klotho抑制IGF1对垂体负反馈作用,促进GH分泌,而GH促进IGF1分泌。此外,Klotho通过GH-IGF1轴、FGF23共同调控体内磷酸盐平衡;该文简要综述了相关研究进展。Klotho was first discovered as an aging-suppressor gene.Klotho protein is highly expressed in the brain and the kidney,but can also serve as a circulating hormone.Evidences suggest that Klotho is involved in calcium phosphate homeostasis,energy metabolism,protection of the cardiovascular system,protection of kidney and anti-aging through membrane receptors and hormone-like effects.Currently available studies support a tight interaction between Klotho and the GH-IGF1 axis,with a complex reciprocal regulation between them.On one hand,increased activity of the GH-IGF1 axis upregulates serum Klotho levels,which in turn inhibits the peripheral activity of IGF1,thus forming a negative feedback loop.On the other hand,klotho abrogates the inhibitory effect of IGF1 in the pituitary,leading to enhanced GH secretion and further increase of IGF1 production,thus forming a positive feedback loop.In addition,Klotho plays an important role in calcium-phosphate metabolism together with GH-IGF1 and FGF23.In this paper,the regulation of Klotho expression and its relationship with GH-IGF1 axis and mineral metabolism are reviewed briefly.

关 键 词：Koltho基因 生长 儿童发育 生长激素 成纤维生长因子23 

分 类 号：R541.4[医药卫生—心血管疾病]