野菊花的化学成分研究  

Chemical constituents from flowers of Chrysanthemum indicum

作　　者：刘磊磊[1] 肖卓炳[1] LIU Lei-lei;XIAO Zhuo-bing(Key Laboratory of Hunan Forest Products and Chemical Industry-Engineering,Jishou University,Zhangjiajie 427000,China)

机构地区：[1]吉首大学林产化工工程湖南省重点实验室,湖南张家界427000

出　　处：《中草药》2018年第22期5254-5258,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(21864012);湖南省自然科学基金资助项目(14JJ6037);张家界市科技局项目(2016FJ2168);林产化工工程湖南省重点实验室开放基金(JDZ201601)

摘　　要：目的研究野菊Chrysanthemum indicum花蕾的化学成分。方法采用薄层色谱、硅胶柱色谱、ODS反相柱色谱及SephadexLH-20凝胶柱色谱等分离技术,对野菊花的化学成分进行分离研究,并运用NMR波谱技术鉴定化合物的结构。结果从野菊花的乙醇提取物中分离并鉴定了14个化合物,分别为豆甾-4-烯-3-酮(1)、棕榈酸金盏菊二醇(2)、棕榈酸16β,22α-二羟基假蒲公英甾醇(3)、α-香树脂醇(4)、乌苏-12-烯-3β,16β-二羟基(5)、12-烯-3β-羟基-乌苏-11-酮(6)、山金车二醇(7)、马尼拉二醇(8)、12-烯-3β-羟基-齐墩果-11-酮(9)、木犀草素(10)、芹菜素(11)、芹菜素-7,4′-二甲醚(12)、芫花素(13)、1-亚油酸甘油酸酯(14)。结论化合物1～6、10～12和14为首次从野菊花中分离得到。Objective To study chemical constituents from the flowers of Chrysanthemum indicum.Methods The chemical constituents of C.indicum were isolated and purified by various chromatographic techniques,including thin-layer chromatography, silica gel,ODS reversed-phase silica gel,and Sephadex LH-20for column chromatography,and their structures were identified by NMR spectral analysis.Results Fourteen compounds were isolated and identified as stigrnata-4-ene-3-one (1),calenduladiol-3J3-O- palmitate (2),1613,22α-dihydroxypseudotaraxasterol-3β-O-palmitate (3),α-am37rin (4),urs-12-ene-313,16β-diol (5),3β-hydroxyurs- 12-ene-ll-one (6),arnidiol (7),maniladiol (8),313-hydroxyolean-12-ene-ll-one (9),luteolin (10),apigenin (11),apigenin-7,4'- dimethyl ether (12),genkavanin (13),and.1-1inoleic acid glycerate (14).Conclusion Compounds 1--6,10--12,and 14are isolated from the flowers of C.indicum for the first time.

关 键 词：野菊花 棕榈酸16β 22α-二羟基假蒲公英甾醇 α-香树脂醇 木犀草素 芹菜素 

分 类 号：R284.1[医药卫生—中药学]