龟龄集对衰老引起的学习记忆功能障碍的改善作用  

Effects of Guilingji on improving learning and memory dysfunction caused by aging

作　　者：赵思俊[1,2] 赵晓喆 柳花兰 高晓霞 田俊生[1] 张蕻[2] 秦雪梅 ZHAO Si-jun;ZHAO Xiao-zhe;LIU Hua-lan;GAO Xiao-xia;TIAN Jun-sheng;ZHANG Hong;QIN Xue-mei(Modem Research Center for Traditional Chinese Medicine of Shanxi University,Taiyuan 030006,China;Shanxi Ifistimte for Food and Dmg Control,Taiyuan 030001,China;Shanxi Guangyuyuan Chinese Medicine Co.,Ltd.,Jinzhong 030800,China)

机构地区：[1]山西大学中医药现代研究中心,山西太原030006 [2]山西省食品药品检验所,山西太原030001 [3]山西广誉远国药有限公司,山西晋中030800

出　　处：《中草药》2018年第22期5352-5357,共6页Chinese Traditional and Herbal Drugs

基　　金：山西省科技重点研发计划(201603D3113006);山西省科技创新重点团队(201605D131045-18):山西省重点实验室(201605D111004).

摘　　要：目的探讨龟龄集对衰老引起的学习记忆功能障碍的改善作用。方法分别应用D-半乳糖致亚急性衰老小鼠模型和自然衰老大鼠模型,考察龟龄集对小鼠跳台实验和大鼠Morris水迷宫等学习记忆功能指标的改善作用,同时考察其对大鼠胸腺、脾脏、睾丸、附睾脏器指数和血液生化指标的影响。结果龟龄集能显著延长模型小鼠的跳台潜伏期(P<0.05),明显减少5min内的错误次数(P<0.05、0.01)。龟龄集能够缩短自然衰老大鼠定位航行逃逸潜伏期(P<0.01),延长空间探索象限滞留时间(P<0.05、0.01),增加进入平台次数(P<0.05);能够增加睾丸、胸腺、脾脏指数(P<0.05),降低血清中丙氨酸转氨酶(ALT)水平(P<0.05)。结论龟龄集具有明显改善衰老引起的学习记忆功能减退的作用,同时在提高免疫、改善生殖、保护肝脏方面也具有一定的作用。Objective To explore the effects of Guilingji on improving learning and memory dysfunction caused by aging. MethodsThe mouse model of subacute aging caused by D-galactose and the rat model of natural aging were used respectively to imitate learning and memory dysfunction caused by aging. The effects of Guilingji on improving of learning and memory function index were focused in the diving platform experiment and the Morris water maze experiment. At the same time, the effect of that on rat organ index and blood biochemical index were investigated. Results Guilingji can significantly prolong step down latency(P < 0.05) and reduce the number of errors within 5 min(P < 0.05, 0.01) of the model mice. It can shorten positioning navigation escape incubation period(P < 0.01), extend the space exploration quadrant retention time(P < 0.05, 0.01), and increase the number of access to the platform(P < 0.05). Guilingji can increase testicular, thymus and spleen index(P < 0.05) and reduce the ALT content in serum(P < 0.05). Conclusion Guilingji can obviously improve the impairment of learning and memory function caused by aging. It also has some good effects on enhancing immunity, improving reproductive capacity, and protecting liver.

关 键 词：龟龄集 D-半乳糖 自然衰老大鼠 学习记忆功能 脏器指数 

分 类 号：R285.5[医药卫生—中药学]