阿霉素肾病模型及其病理机制研究进展  

Research progress on adriamycin nephropathy model and its pathological mechanism

作　　者：贺升升 李爱平[1] 张王宁 秦雪梅[1] HE Sheng-sheng;LI Ai-ping;ZHANG Wang-ning;QIN Xue-mei(Modem Research Center for Traditional Chinese Medicine of Shanxi University,Taiyuan 030006,China;College of Chemistry and Chemical Engineering of Shanxi University,Taiyuan 030006,China)

机构地区：[1]山西大学中医药现代研究中心,山西太原030006 [2]山西大学化学化工学院,山西太原030006

出　　处：《中草药》2018年第22期5426-5434,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目"多效中药黄芪的定向药效化学成分研究"(31570346)

摘　　要：阿霉素肾病模型是目前公认的能够较好模拟人类肾病的模型之一,其动物模型的表现类似于临床的人类肾病综合征,其细胞模型因能够较好地模拟肾小球足细胞的基本功能而广泛应用于肾病的病理机制研究。从阿霉素肾病的动物模型和体外细胞模型入手,旨在系统地阐述阿霉素肾病模型的造模方法和病理机制,为基于肾脏疾病的药物研发提供科学、合理的药理学实验模型参考,为开展中药复方治疗肾病的作用机制研究提供依据。Adriamycin-induced nephritic model is one of the well-recognized models in simulating human nephropathy,whose clinical manifestations of animal models are similar to human nephrotic syndrome,and its cell models are widely used in the pathological mechanism study of nephropathy because of the well-simulated basic fimction of glomerular podocyte.Based on the animal models and cell models in vitro of adriamycin nephropathy,this study aims at reviewing the modelling method and pathological mechanism of adriamycin-induced nephritic model in order to provide a scientific and rational pharmacological experimental model reference for drug research and development based on kidney disease,and provide evidence for the research of the mechanism of Chinese herbal compound in the treatment of nephropathy.

关 键 词：阿霉素肾病 动物模型 细胞模型 病理机制 足细胞 蛋白尿 

分 类 号：R285[医药卫生—中药学]