从心律失常与心衰并发症的最新临床进展解析中医治疗"脉结代,心动悸"的科学内涵  

New evidence supporting “intermittent pulse and severe palpitation” theory for prevention and treatment of complications of atrial fibrillation and heart failure

作　　者：解微微[1,2] 高佳明 石羡茹 王泰一 崔英[1,2] 朱彦[1,2] XIE Wei-wei;GAO Jia-ming;SHI Xian-ru;WANG Tai-yi;CUI Ying;ZHU Yah(Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Research and Development Center of Traditional Chinese Medicine,Tianjin International Joint Academy of Biotechnology and Medicine,Tianjin 300457,China)

机构地区：[1]天津中医药大学天津市现代中药国家重点实验室,天津300193 [2]天津国际生物医药联合研究院中药新药研发中心,天津300457

出　　处：《中草药》2018年第22期5448-5455,共8页Chinese Traditional and Herbal Drugs

基　　金：稳心颗粒国际合作项目(2013DFA31620).

摘　　要：国际最新临床结果显示,心力衰竭(简称心衰)和房颤这2种常见的心脏疾病并发率极高。然而现有的治疗药物和手段均仅针对各自疾病的单一靶点,忽略了并发症的复杂因素。基于中医药理论,有希望从组合药物尤其是天然来源的中药复方中找到对心律失常与心衰并发症有效的治疗药物。从现有心衰和心律失常临床用药和治疗手段入手,梳理了治疗这2种疾病的传统中药方剂与单味药,并对经典名方炙甘草汤及其衍生的现代中药如稳心颗粒进行系统探究。结合网络药理学对心衰和心律失常共同靶标进行分析,并对稳心颗粒成分作用靶点进行预测,提出"脉结代,心动悸"有可能是心律失常与心衰的综合临床表现,探讨中医治疗"脉结代、心动悸"的科学内涵。The latest international clinical results show that heart failure and atrial fibrillation are two common heart diseases with extremely high coincidence. However, the existing therapeutic drugs and methods are all aimed at a single target of their respective diseases, ignoring the complex factors of complications. It is hopeful to find effective therapeutic drugs for arrhythmia and complications of heart failure from combination drugs, especially natural Chinese herbal medicines, based on the perspective of Chinese medicine. This article started with the existing clinical medicine and treatment methods for heart failure and arrhythmia, combed the traditional Chinese medicine prescriptions and single herb medicines for treating these two diseases, in which prepared licorice decoction and its derived modern Chinese medicines Wenxin Granule were systematically explored. The common targets of heart failure and arrhythmia and the prediction of the target of Wenxin Granule in the previous period were analyzed by network pharmacology, it was suggested that "intermittent pulse and severe palpitation" may be the comprehensive clinical manifestations of arrhythmia and heart failure. This article traced the origin and interpretation of the scientific connotation of "intermittent pulse and severe palpitation".

关 键 词：心律失常 心力衰竭 稳心颗粒 炙甘草汤 中医药 

分 类 号：R285[医药卫生—中药学]