山玉兰叶化学成分研究  

Chemical constituents from leaves of Magnolia delavayi

作　　者：谢章巧 丁林芬 王德升 晏通 程彬 宋流东 吴兴德[2] XIE Zhang-qiao;DING Lin-fen;WANG De-sheng;YAN Tong;CHENG Bin;SONG Liu-dong;WU Xing-de(School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming 650500,China;State Key Laboratory of Phytochemistry and Plant Resources in Western Cfiina,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China)

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [2]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201

出　　处：《中草药》2018年第21期5040-5045,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(21662023;81773611);云南省科技厅-昆明医科大学应用基础研究联合专项基金项目(2017FE467-016);云南省教育厅科学研究基金指导性项目(2017zDX156);云南省应用基础研究面上项目(2015FB173)

摘　　要：目的对山玉兰Magnolia delavayi叶的化学成分进行研究。方法采用MCI、硅胶、Sephadex LH-20、HPLC等多种色谱技术进行分离纯化,根据波谱数据鉴定化合物的结构。结果从山玉兰叶95%乙醇提取物中分离得到14个化合物,分别鉴定为(2E)-3,7,11-trimethyl-2,10-dodecadien-l,6,7-triol(1)、(2E,6E)-3,7,11-trimethyl-2,6-dodecadien-l,10,11-triol(2)、黑麦草内酯(3)、松脂醇(4)、丁香脂素(5)、梣皮树脂醇(6)、桉脂素(7)、连翘脂素(8)、松柏醛(9)、3,4,5-三甲氧基肉桂醇(10)、3-吲哚甲醛(11)、3-吲哚乙醇(12)、3,4-二甲氧基苯甲酸(13)、3,4-二甲氧基苯酚(14)。结论所有化合物均为首次从该植物中分离得到,并且首次报道化合物1的1H-和13C-NMR数据。Objective To study the chemical constituents from the leaves of Magnolia delavayi.Methods The chemical constituents were isolated and purified by column chromatography on silica gel,Sephadex LH-20,MCI,and HPLC.Their structures were identified based on spectroscopic data.Results Fourteen compounds were isolated from 95% ethanol aqueous extract of M.delavayi and the structures were identified as(2 E)-3,7,11-trimethyl-2,10-dodecadien-l,6,7-triol(1),(2 E,6 E)-3,7,11-trimethyl-2,6-dodecadien-l,10,11-triol(2),loliolide(3),pinoresinol(4),syringaresinol(5),medioresinol(6),eudesmin(7),phillygenin(8),coniferaldehyde(9),3,4,5-trimethoxycinnamyl alcohol(10),indole-3-carboxaldehyde(11),indole-3-ethanol(12),3,4-dimethoxy-benzoic acid(13),and 3,4-dimethoxyphenol(14).Conclusion All compounds are isolated from this plant for the first time.In addition,the 1 H-and 13 C-NMR spectroscopic data are reported for the first time in the current study.

关 键 词：山玉兰 黑麦草内酯 松脂醇 3-吲哚甲醛 3 4-二甲氧基苯酚 

分 类 号：R284.1[医药卫生—中药学]