基于mTOR信号通路探讨中医药干预冠心病研究进展  

Research progress on intervention of traditional Chinese medicine on coronary heart disease through mTOR signaling pathway

作　　者：王鹏伟 高杉[1] 徐一兰[1] 李琳[1] 于春泉[1] WANG Peng-wei;GAO Shan;XU Yi-lan;LI Lin;YU Chun-quan(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津中医药大学,天津300193

出　　处：《中草药》2018年第21期5191-5196,共6页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究("973")计划项目(2014CB542902);天津市高等学校创新团队建设规划(TD13-5049)

摘　　要：雷帕霉素靶蛋白(mammalian target of rapamycin,m TOR)信号通路具有调控细胞生长、自噬、增殖和凋亡等生物学功能,在肿瘤、心脑血管疾病中发挥着重要作用。近年来mTOR信号通路的磷酸腺苷活化蛋白激酶(AMP-activated protein kinase,AMPK)/mTOR和蛋白激酶B(Akt)/mTOR通路日益受到重视。基于2条通路与冠心病关系及中医药的干预作用进行综述。The mammalian target of rapamycin (mTOR)signaling pathway has biological functions such as regulation of cell growth, autophagy,proliferation,and apoptosis,and plays an important role in tumor,cardiovascular,and cerebrovascular diseases.In recent years,two pathways of mTOR signaling,AMPK (AMP-dependent protein kinase)/mToR and Akt (phosphoinositide-3kinase)/mTOR pathway,have gained increasing attention.This paper mainly reviews the relationship between two pathways of mTOR and development of coronary heart disease,as well as the intervention of traditional Chinese medicine.

关 键 词：磷酸腺苷活化蛋白激酶 蛋白激酶B 雷帕霉素靶蛋白 冠心病 中医药 

分 类 号：R285[医药卫生—中药学]